Lg Life Sciences, Limited

Lg Chem, Ltd

Vasily Artemov

Tae Hun Kim

Heui Sul Park

Eun Sil Choi

Hyo Shin Kwak

Young Kwan Kim

Sung Bae Lee

Soon Ha Kim

Hyoung Jin Kim

Sung Pil Choi

Sang Dae Lee

Sun Young Koo

Hyun Woo Joo

Sang Yun Park

Deok Seong Park

Wan Su Park

Ki Chul Koo

Geun Tae Kim

Cheol Kyu Jung

Myoung Yeol Kim

Ok Ku Park

Jeong Uk Song

The present application relates to an indole compound represented by formula (1): a pharmaceutically acceptable salt or isomer thereof, a composition for prevention or treatment of necrosis and necrosis-associated diseases, and a method for preparing the composition, the composition comprising the indole compound or the pharmaceutically acceptable salt or isomer thereof as an active ingredient.

Indole compound as inhibitor of necrosis

The present invention relates to thioaryl derivatives of Formula 1 as defined in the specification, a method for preparing the same, a pharmaceutical composition comprising the same and use thereof. The thioaryl derivatives of Formula 1 according to the present invention promote GLP-1 formation in the gastrointestinal tract and improve insulin resistance in macrophages, pancreas cells, etc. due to anti-inflammatory action, and can accordingly be effectively used for preventing or treating diabetes, complications of diabetes, inflammation, obesity, non-alcoholic fatty liver, steatohepatitis or osteoporosis.

Thioaryl derivatives as GPR120 agonists

The present invention relates to novel compounds which are effective as an inhibitor for xanthine oxidase, a process for preparing the same, and a pharmaceutical composition comprising a therapeutically effective amount of the same.

Compounds effective as xanthine oxidase inhibitors, method for preparing the same, and pharmaceutical composition containing the same

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Daejeon, South Korea

Vasily Artemov