Helmholtz Zentrum Munchen Deutsches Forschungszentrum Fur Gesundheit Und Umwelt

The General Hospital Corporation

Technische Universitat Munchen

Visen Medical, Inc.

Ludwig-Maximilians-Universitat München

Helmholtz Zentrum Muenchen Deutsches Forschungszentrum Fuer Gesundheit Und Umwelt Gmbh

Universitat Der Bundeswehr Munchen

Vasilis Ntziachristos

Daniel Razansky

Farouc Amin Jaffer

Jorge Ripoll

Ralph Weissleder

Amir Rozental

Jorge Ripoll Lorenzo

Karen Madden

Günther Dollinger

Georg Michael Wissmeyer

Rami Shnaiderman

George Themelis

Katia Parodi

Stephan Kellnberger

Miguel Angel Pleitez Rafael

Nikolaos Deliolanis

Giannis Zacharakis

Dmitry Bozhko

Maximilian Koch

Mark J Niedre

Amir Rosenthal

Jannis Schauer

Hans Peter Wieser

Heinrich Ruser

Ludwig Prade

Yuanhui Huang

Andreas Buehler

Christian Zakian

George Sergiadis

Pouyan Mohajerani

Juan Aguirre Bueno

Stratis Tzoumas

Ivan Olefir

Walter Assmann

R Nika Mendelev (Nudelman)

Stefan Morscher

Angelica Ale

Mathias Schwarz

R Nika Nudelman

A hybrid NIRF/IVUS imaging probe containing i) a spatially-truncated optical lens a substantially-planar surface of which is inclined with respect to an axis to reflect light, transmitted between proximal and distal ends of the probe, internally into a body of the lens, and ii) an acoustic transducer disposed sequentially with the optical lens on the axis of the probe while, at the same time, the optical and electrical members of the probe transmitting the radiative and mechanical energies (which the probe exchanges with a target bodily vessel) are parallel to one another within the housing of the probe. A method for operating the probe resulting in formation of spatially co-registered optical and acoustic images of the target. Related imaging system and computer-program product.

Miniaturized intravascular fluorescence-ultrasound imaging catheter

A method and an apparatus for determining information regarding the location of energy deposition of an ion beam, in particular a proton beam, in an absorptive medium, such as in the tissue of a patient undergoing radiation therapy.

Matched filter in ionoacoustic signal processing for ion beam range determination and dosimetry

The present invention relates to a sensor for non-invasive optoacoustic measurements of biomechanical and/or morphological features of skin and/or other tissue.

Sensor for tissue measurements

The invention relates to a device and a method for optoacoustic sensing, wherein an irradiation unit is configured to generate at least one train of periodic pulses of electromagnetic energy, the pulses of the at least one train of periodic pulses exhibiting a pulse duration and repetition rate, and to irradiate a target with the generated train of periodic pulses. A detection unit is configured to detect acoustic waves generated in the target and to generate an according detection signal, the detection signal comprising, for each train of the at least one train of periodic pulses, detection signal components at a plurality of discrete frequencies in the frequency domain, the discrete frequencies being spaced from each other by a frequency spacing corresponding to the repetition rate of the pulses of the at least one train of periodic pulses. Further, a processing unit is configured to modify the detection signal in the frequency domain to obtain a modified detection signal, and to derive at least one property of the target based on the modified detection signal.

Device and method for optoacoustic sensing

The invention relates to a device () for endoscopic optoacoustic imaging comprising an imaging unit () configured to be at least partially inserted into an object (), said imaging unit () comprising an irradiation unit () configured to irradiate a region of interest () inside the object () with electromagnetic radiation and a detection unit () comprising at least one ultrasound transducer configured to detect ultrasound waves generated in the region of interest () in response to irradiating the region of interest () with the electromagnetic radiation and to generate according detection signals, wherein the at least one ultrasound transducer exhibits a field of view () being at least partially located in the irradiated region of interest (). A position stabilizing structure () with an outer face () and an interior () is configured to stabilize and/or fix the imaging unit () in a position and/or orientation in the object () by bringing the outer face () of the position stabilizing structure () into contact with the object (). The device () further comprises a processing unit () configured to generate an optoacoustic image () of the region of interest () based on the detection signals.

Device for endoscopic optoacoustic imaging, in particular for endoscopic optoacoustic imaging of cavities and hollow objects

The invention relates to a device () and an according method for optoacoustic imaging of an object. The device () comprising an irradiation unit for irradiating a region of interest () of the object with electromagnetic radiation (), in particular light, and a detection unit () for detecting acoustic, in particular ultrasonic, waves generated in the region of interest () of the object upon irradiation with the electromagnetic radiation (), wherein the detection unit () is configured to detect the acoustic waves at one or more point-like detection locations, which are located outside of the region of interest () of the object. The point-like detection locations can be given by, e.g., focus points () of acoustic detection elements (), point-like detection elements or point-like or pinhole apertures. The invention allows for improved and reliable optoacoustic imaging, in particular in view of dermatology applications.

Device and method for optoacoustic imaging of an object

A sensor () comprises a waveguide () having a longitudinal axis and an end face (), the waveguide () comprising a Bragg grating (). The sensor comprises at least one reflector () on the end face () of the waveguide (). An optical resonator () is formed by the Bragg grating (), the at least one reflector (), and an inner portion of the optical resonator () between the Bragg grating () and the at least one reflector (). The inner portion of the optical resonator () extends within a portion of the waveguide (). The sensor () comprises a detector () configured to detect at least one spectral characteristic of the optical resonator () or a change of at least one spectral characteristic of the optical resonator ().

Sensor comprising a waveguide with optical resonator and sensing method

The invention relates to a system for endoscopic imaging comprising a light source configured to generate light and an, in particular rigid, insertion portion configured to be inserted into an object and comprising a distal end, a proximal end and at least one light guiding path. The system further comprises a first imaging device mounted at the proximal end of the insertion portion and optically coupled to the light guiding path, the first imaging device comprising a plurality of first detecting elements exhibiting a first sensitivity to light. A flexible guiding portion comprising a distal end and a proximal end is provided to guide a second part of the light emanating from the medium from the distal end of the guiding portion to the proximal end of the guiding portion. A second imaging device provided at the proximal end of the flexible guiding portion comprises a plurality of second detecting elements exhibiting a second sensitivity to light, the second sensitivity of the second detecting elements being higher than the first sensitivity of the first detecting elements. A control unit is configured to derive at least one third image of the medium based on image data of the at least one first image of the medium and image data of the at least one second image of the medium. The invention further relates to a corresponding method for processing images.

System for endoscopic imaging and method for processing images

The invention relates to a device () and a corresponding method for mid-infrared microscopy and/or analysis, the device () comprising at least one radiation unit () configured to generate radiation () of time-varying intensity, the radiation () comprising one or more wavelengths in the mid-infrared spectral range, at least one refractive and/or reflective optical unit () which is configured to focus and/or direct the radiation () to at least one region or point of interest () located on and/or with-in an object (), at least one detection unit () configured to detect ultrasound waves () emitted by the object () at the at least one region or point of interest () in response to an interaction of the radiation () with the object () and to generate according detection signals, and an evaluation unit () configured to derive infor-mation regarding at least one property of the object () from the detection signals and/or to generate a spatial and/or spatio-temporal distribution of the detection sig-nals or of information derived from the detection signals obtained for the at least one region or point of interest () located on and/or within the object ().

Device and method for mid-infrared microscopy and analysis

A multi-modal catheter combining at least NIRF and IVUs imaging channels used to reveal integrated biological and structural features of a lumen intravascularly imaged through flowing blood in vivo and corrected for distance-related attenuation and/or scattering parameters of in vivo blood to compensate for discovered overestimation of the degree of in-vivo-blood attenuation of NIRF signal Enhancing the sensitivity of detection of vascular injury and/or plaque deposition beyond the capability of a standalone IVUS imaging as a result of the use of such corrected catheter.

Hybrid systems and methods for multi-modal acquisition of intravascular imaging data and counteracting the effects of signal absorption in blood

The invention relates to a device () and a corresponding method for thermoacoustic sensing, in particular thermoacoustic imaging, the device () comprising: a) an irradiation unit () configured to generate electromagnetic and/or particle energy exhibiting a first modulation, the first modulation comprising at least one frequency and to continuously emit the energy towards a target (), whereby acoustic waves are continuously generated in the target, the acoustic waves exhibiting a second modulation, the second modulation comprising the at least one frequency and/or a harmonic frequency of the at least one frequency; b) a detection unit () configured to simultaneously detect the acoustic waves exhibiting the second modulation while the energy exhibiting the first modulation is being continuously emitted towards the target (); and c) a processing unit () configured to determine at least one thermoacoustic value of an amplitude and/or a phase of the second modulation of the acoustic waves at the at least one frequency and/or at a harmonic frequency of the at least one frequency. The invention allows for fast and economic thermoacoustic sensing, in particular imaging of a region of interest of an object.

Device and method for frequency-domain thermoacoustic sensing

A device and an according method for multispectral optoacoustic imaging of an object is provided comprising: an irradiation unit configured to irradiate the object with electromagnetic radiation at two or more different irradiation wavelengths the electromagnetic radiation having a time-varying intensity; a detection unit configured to detect acoustic waves generated in the object upon irradiating the object with the electromagnetic radiation at the different irradiation wavelengths; and a processing unit configured to reconstruct images of the object based on the detected acoustic waves generated in the object at each of the irradiation wavelengths and to determine a spatial distribution of at least one first concentration value, which relates to a concentration of at least one electromagnetic radiation absorber in the object.

Device and method for multispectral optoacoustic imaging

Disclosed is a method of determining information regarding the location of energy deposition of an ion beam, in particular a proton beam, in an absorptive medium, in particular in the tissue of a patient undergoing radiation therapy, comprising the following steps:

Method and apparatus for determining an energy deposition of an ion beam

An imaging device includes (a) a light source device arranged to illuminate a sample under investigation with illumination light, (b) a detector device arranged to collect a plurality of images including at least one sample light image backscattered by the sample, and at least one marker light image originating from at least one marker substance in the sample, and (c) a processor device adapted to process the at least one sample light image.

Method and device for multi-spectral photonic imaging

An imaging device configured for optoacoustic imaging of an object, including an illumination device including optical components arranged to illuminate the object, a detector device comprising an array of detector elements arranged in a tank and arranged to detect acoustic signals created in the object, and a container device including a tank arranged to accommodate the detector device, the object and a matching transmission medium, a holding device adapted to position and move the object relative to the illumination device and the detector device, wherein the optical components are arranged in the tank to illuminate the object from different directions.

Imaging device and method for optoacoustic imaging of small animals

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Munich, Germany

Vasilis Ntziachristos