Alphora Research Inc.

Varghese Rexon

Boris Gorin

Joshua Clayton

Craig Edward Dixon

Dino Alberico

Ryan Beharrilall

Joshua A Clayton

Anti-virally active carbanucleosides such as entecavir are prepared by a process which utilizes, throughout the synthesis, an aromatic protectant group for the hydroxyl and the alkyl hydroxy groups of the starting material, removed as the final step of a multi-step synthesis. Such protectant groups yield intermediates which are solid and therefore easily purified at various stages of the process, for an economical and relatively fast process for synthesizing the final product.

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Brampton, Canada

Varghese Rexon