The Medical Research, Infrastructure and Health Services Fund of the Tel Aviv Medical Center

Bar-Ilan University

Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.

Varda Deutsch

Tamar Tennenbaum

Ron Goldstein

Hermona Soreq

Dan Grisaru

Chava Perry

Marjorie Pick

The present invention relates to animal model systems comprising a chimera between an avian embryo and a mammalian organism. Specifically, chimeric model systems comprising normal, diseased or genetically transformed mammalian cells and tissues transplanted into avian embryos, and uses thereof for in vivo testing of drugs and therapeutic modalities are disclosed.

Chimeric avian-based screening system containing mammalian grafts

The present invention describes the use of an AChE-R-derived peptide, also known as ARP, as an inducer of hemopoietic cell differentiation and expansion, specifically for the granulocytic population. In addition, the use of ARP as an inducer of thrombopoietin and pro-inflammatory cytokines is also presented. ARP may further be used in the pre-transplant priming of hematopoietic stem cells. Other uses and methods utilizing ARP are also described herein.

Acetylcholinesterase (ACHE)-derived peptide as an inducer of granulocytopoiesis, uses and methods thereof

Growing community of inventors

Jerusalem, Israel

Varda Deutsch