Research Development Foundation

Vannary Tieng Caulet

Karl-Heinz Krause

Michel Dubois-Dauphin

Provided herein are methods and compositions for a suicide gene approach comprising an expression vector comprising a cell cycle-dependent promoter driving the expression of a suicide gene. Also provided herein are methods to render proliferative cells sensitive to a prodrug after transplantation but avoids expression of the suicide gene in post-mitotic cells, such as neurons.

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Geneva, Switzerland

Vannary Tieng Caulet