Erregierre S.p.a.

Proter S.p.a.

Vanna Springolo

Egidio Molinari

Germano Coppi

Antonio Bonaldi

Mario Ercole Scevola

Several methods are disclosed for the preparation of oral pharmaceutical forms with delayed release of rhein and its derivatives. The pharmaceutically active ingredient is provided in the form of granules, coated with at least one of polyvinylpyrrolidone, shellac and hydroxypropylmethyl cellulose. The desired effect of the coating is to slow release of the pharmaceutically active ingredient by resisting gastric juices in the stomach, but gradually dissolving in the intestines.

Galenic formulations for oral use of rhein derivatives with delayed

Salification products between cholic acids (chenodeoxicholic and ursodeoxycholic acid) and trimebutyne in the molar ratio 1:1 or 2:1 have been prepared. These new salts show a pharmacotherapeutic action, which, as a whole, is not found in other known drugs, and which makes them useful for the treatment of diskinesiae, biliary dyspepsiae, cholecystopathies, and for the normalization of the kinesis of the intestinal gastro-biliary tract.

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Milan, Italy

Vanna Springolo