Glaxo Group Limited

Pliva, Farmaceutska, Kemijska, Prehrambena I Kozmeticka Industrija,

Glaxosmithkline Istrazivacki Centar Zagreb D.o.o.

Pliva Farmaceutska

Vanja Vela

Antun Hutinec

Goran Kragol

Sulejman Alihodzic

Ognjen Culic

Martina Bosnar

Gorjana Lazarevski

Zorica Marusic-Istuk

Zorica Marusic Istuk

Nikola Marjanovic

Dubravko Jelic

Bo Zidar Su Skovi C

Mira Bun Ci C

Mira Buncic

Bozidar Suskovic

Vesna Erakovic

Marija Ribic

Vesna Erakovic Haber

Vanesa Ivetic

Marija Tomaskovic

Berislav Bosnjak

Marija Leljak

Vesna Munic

The present invention relates to novel semi-synthetic macrolides having anti-inflammatory activity. More particularly, the invention relates to 14- and 15-membered macrolides substituted at the 4&#x2033; position, to their pharmaceutically acceptable derivatives, to processes and intermediates for their preparation, to pharmaceutical compositions containing them and to their activity and use in the treatment of inflammatory diseases and conditions in humans and animals, especially those diseases associated with excessive secretion of TNF-&#x3b1;, IL-1, IL-8, IL-2 or IL-5; and/or inhibitor of excessive lymphocyte proliferation; and/or excessive granulocyte degranulation.

Macrolides with anti-inflammatory activity

The present invention relates to novel semi-synthetic macrolides having anti-inflammatory activity. More particularly, the invention relates to 14- and 15-membered macrolides lacking cladinose sugar substituted at the C-3 position, to their pharmaceutically acceptable derivatives, to processes and intermediates for their preparation, to pharmaceutical compositions containing them and to their activity and use in the treatment of inflammatory diseases and conditions in humans and animals, especially those diseases associated with excessive secretion of TNF-&#x3b1;, IL-1, IL-6, IL-8, IL-2 or IL-5; and/or inhibitor of excessive lymphocyte proliferation; and/or excessive granulocyte degranulation.

Decladinosyl-macrolides with anti-inflammatory activity

The invention relates to the process for the preparation of new derivatives of amino-ascorbic acid, their acid and alkali salts, processes for preparation and action. According to this invention derivatives of amino-ascorbic acid are prepared by three types of reactions: 1. reductive alkylation of amino-ascorbic acid; 2. alkylation of primary and secondary amines with halogen-ascorbic acid and 3. acylation of amino-ascorbic acid.

Derivatives of amino-ascorbic acid, the processes for their preparation

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Zagreb, Croatia

Vanja Vela