Baylor University

Oxigene, Inc.

Other

Vani P Mocharla

Kevin G Pinney

Zhi Chen

James Michael Dorsey

George R Pettit

David J Chaplin

Klaus Edvardsen

Joseph Anthony Prezioso

Charles M Garner

Anupama Shirali

Mallinath Hadimani

Ronald W Pero

David I Sherris

Maria Del Pilar Mejia

Maria Del Mejia

Raymond Kessler

Usha Ghatak, Legal Representative

Usha R Ghatak, Legal Representative

Jimmy Kessler

Anjan Ghatak

A diverse set of tubulin binding agents have been discovered which are structurally characterized, in a general sense, by a semi-rigid molecular framework capable of maintaining aryl-aryl, pseudo pi stacking distances appropriate for molecular recognition of tubulin. In phenolic or amino form, these ligands may be further functionalized to prepare phosphate esters, phosphate salts, phosphoramidates, and other prodrugs capable of demonstrating selective targeting and destruction of tumor cell vasculature.

Tubulin binding ligands and corresponding prodrug constructs

Tubulin binding agents and corresponding prodrug constructs

Treatment of warm-blooded animals having a tumor or non-malignant hypervascularation, by administering a sufficient amount of a cytotoxic agent formulated into a phosphate prodrug form having substrate specificity for microvessel phosphatases, so that microvessels are destroyed preferentially over other normal tissues, because the less cytotoxic prodrug form is converted to the highly cytotoxic dephosphorylated form.

Compositions and methods for use in targeting vascular destruction

A diverse set of tubulin binding ligands have been discovered which are structurally characterized, in a general sense, by a semi-rigid molecular framework capable of maintaining aryl&mdash;aryl, pseudo pi stacking distances appropriate for molecular recognition of tubulin. In phenolic or amino form, these ligands may be further functionalized to prepare phosphate esters, phosphate salts, and phosphoramidates capable of demonstrating selective targeting and destruction of tumor cell vasculature.

Description anti-mitotic agents which inhibit tubulin polymerization

Anti-mitotic agents which inhibit tubulin polymerization

Growing community of inventors

Waco, TX, United States of America

Vani P Mocharla