Council of Scientific and Industrial Research

Vangala Santhosh Reddy

Ahmed Kamal

Gajjela Bharath Kumar

Chityal Ganesh Kumar

Anver Basha Shaik

Challa Ratna Reddy

Mahesh Rasala

Visweswara Sastry

Shaik Anver Basha

Pyrazole linked benzimidazole conjugates and a method for synthesis of one or more compounds having a pyrazole linked benzimidazole conjugate, particularly pyrazole linked benzimidazole conjugates that are useful as potential antitumor agents against human cancer cell lines, such as leukemia, non-small cell lung cancer, colon cancer, CNS cancer, melanoma, ovarian cancer, renal cancer, prostate cancer and breast cancer. The process comprises the step of oxidative cyclization of o-phenylenediamines and 3-phenyl-1H-pyrazole-5-carbaldehydes with sodium metabisulphite in ethanol/methanol solvent system at a desired temperature for a period of time to obtain the pyrazole linked benzimidazole conjugate.

Pyrazole linked benzimidazole conjugates and a process for preparation thereof

The present invention relates to a pyrazolochalcone of formula A useful as potential antitumor agent against human cancer cell lines and a process for the preparation thereof. Formula A wherein, R1, R2, R3, R4, R5=H, Cl, F, CH, OCH, 3,4(OCHO) X=H, Cl, CH, OCH, 3,4(OCHO), NH, NO, OH, dotted line indicates optionally cyclic structure.

Pyrazolochalcones as potential anticancer agents

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Hyderabad Telangana, India

Vangala Santhosh Reddy