Eisai Company, Limited

Eisai R&d Management Co., Ltd.

Eisai R & D Development Co., Ltd.

Vanessa Palmer

Afzal Khan

Piotr Pawel Graczyk

Hirotoshi Numata

Hitoshi Oinuma

Gurpreet Singh Bhatia

Darren Peter Medland

The present invention provides novel compounds of formula (I) and their use in the inhibition of c-Jun N-terminal kinases. The present invention further provides the use of these compounds in medicine, in particular in the prevention and/or treatment of neurodegenerative disorders related to apoptosis and/or inflammation. 

JNK inhibitors

The present invention relates to novel 3,5-substituted 7-azaindole compounds of formula (I), their use in the inhibition of c-Jun N-terminal kinases, their use in medecine and particularly in the prevention and/or treatment of neurodegenerative disorders related to apoptosis and/or inflammation. The invention also provides processes for manufacture of said compounds, compositions containing them and processes for manufacturing such compositions. 

7-azaindoles as inhibitors of c-Jun N-terminal kinases for the treatment of neurodegenerative disorders

The present invention provides novel compounds of formula I and their use in the inhibition of c-Jun N-terminal kinases. The present invention further provides the use of these compounds in medicine, in particular in the prevention and/or treatment of neurodegenerative disorders related to apoptosis and/or inflammation.

Jun kinase inhibitors

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London, United Kingdom

Vanessa Palmer