Texas Biotechnology Corporation

Encysive Pharmaceuticals, Inc.

Vanessa O Grabbe

Ronald J Biediger

Bore G Raju

Robert V Market

Ian Leslie Scott

Jamal M Kassir

Shuqun Lin

George W Holland

Chengde Wu

Timothy P Kogan

Karin M Keller

Timothy P Kogan, Deceased

Raju G Bore

Ian L Scott

Timothy P Di Kogan

A method for the inhibition of the binding of &agr;,&bgr;,integrin to its receptors, for example VCAM-1 (vascular cell adhesion molecule-1) and fibronectin; compounds that inhibit this binding; pharmaceutically active compositions thereof; and the use of the compounds either as above, or in formulations for the control or prevention of diseases states in which &agr;,&bgr;,is involved.

Compounds that inhibit the binding of integrins to their receptors

A method for the inhibition of the binding of &agr;,&bgr;,integrin to its receptors, for example VCAM-1 (vascular cell adhesion molecule-1) and fibronectin; compounds that inhibit this binding; pharmaceutically active compositions comprising such compounds; and the use of such compounds either as above, or in formulations for the control or prevention of diseases states in which &agr;,&bgr;,is involved.

N, N-disubstituted amides that inhibit the binding of integrins to their receptors

A method for the inhibition of the binding of .alpha..sub.4 .beta..sub.1 integrin to its receptors, for example VCAM-1 (vascular cell adhesion molecule-1) and fibronectin; compounds that inhibit this binding; pharmaceutically active compositions comprising such compounds; and the use of such compounds either as above, or in formulations for the control or prevention of diseases states in which .alpha..sub.4 .beta..sub.1 is involved.

Growing community of inventors

Sugar Land, TX, United States of America

Vanessa O Grabbe