H. Lundbeck A/s

University of Iowa Research Foundation

Alder Biopharmaceuticals, Inc.

Vanessa Lisbeth Rubin

John A Latham

Benjamin H Dutzar

Ethan Wayne Ojala

Pei Fan

Daniel S Allison

Jens J Billgren

Erica Ann Stewart

Michelle Scalley-Kim

Charlie Karasek

Jenny Mulligan

Maria-Cristina Loomis

Katherine Lee Hendrix

Jeffrey T L Smith

Leon F Garcia-Martinez

Leon F Garcia-martinez

Andrew F Russo

Adisa Kuburas

Levi P Sowers

Bianca Mason

Katherine Lee Hendricks

Jeffrey TL Smith

The present invention is directed to antagonistic antibodies and antigen binding fragments thereof having binding specificity for PACAP. These antibodies inhibit, block or neutralize at least one biological effect associated with PACAP, e.g., vasodilation. In exemplary embodiments these antibodies and antigen binding fragments thereof may comprise specific V, V, and CDR polypeptides described herein. In some embodiments these antibodies and antigen binding fragments thereof bind to and/or compete for binding to specific epitope(s) on human PACAP. The invention is further directed to using these antagonistic anti-PACAP antibodies, and binding fragments thereof, for the diagnosis, assessment, and treatment of diseases and disorders associated with PACAP and conditions where antagonism of PACAP-related activities, such as vasodilation, mast cell degranulation, and/or neuronal activation, are therapeutically beneficial, e.g., headache and migraine indications.

Methods of treatment with anti-PACAP antibodies

Anti-PACAP antibodies and uses thereof

This invention relates to methods of screening for anti-PACAP antibodies, or anti-PACAP receptor antibodies, and antigen binding fragments thereof, for potential use in treating or preventing PACAP-associated photophobia or light aversion, and therapeutic compositions containing and methods of using anti-PACAP antibodies, or anti-PACAP receptor antibodies, and antigen binding fragments thereof.

Screening method for identifying anti-PACAP antibodies or antibody fragments suitable for use in treating or preventing PACAP-associated photophobia or light aversion

The present invention is directed to antibodies and antigen binding fragments thereof having binding specificity for PACAP. The antibodies and antigen binding fragments thereof comprise the sequences of the V, V, and CDR polypeptides described herein, and the polynucleotides encoding them. Antibodies and antigen binding fragments described herein bind to and/or compete for binding to the same linear or conformational epitope(s) on human PACAP as an anti-PACAP antibody. The invention contemplates conjugates of anti-PACAP antibodies and binding fragments thereof conjugated to one or more functional or detectable moieties. Methods of making said anti-PACAP antibodies and antigen binding fragments thereof are also contemplated. Other embodiments of the invention contemplate using anti-PACAP antibodies, and binding fragments thereof, for the diagnosis, assessment, and treatment of diseases and disorders associated with PACAP and conditions where antagonism of PACAP-related activities, such as vasodilation, photophobia, mast cell degranulation, and/or neuronal activation, would be therapeutically beneficial.

Treatment of headache, migraine and/or photophobia conditions using humanized anti-PACAP antibodies

Anti-PACAP antibodies

Methods of determining whether anti-PACAP antibodies inhibit PACAP-associated photophobia or light aversion

Humanized anti-PACAP antibodies

Humanized anti-PACAP antibodies and uses thereof

Use of anti-pacap antibodies and antigen binding fragments thereof for treatment, prevention, or inhibition of photophobia

Growing community of inventors

Seattle, WA, United States of America

Vanessa Lisbeth Rubin