Alere San Diego, Inc.

Vance Wong

William D Arnold

Uday Kumar Veeramallu

Scott Rongey

Jonathan Gary

Joseph Buechler

Kelline Marie Rodems

Scott Harold Rongey

Christelle Jost

Brian Noland

The present invention relates in part to diagnosing the occurrence of heart failure, particularly in subjects who exhibit a normal body fluid level of a natriuretic peptide. The present invention further relates in part to assigning an outcome risk (e.g., worsening cardiac function or a mortality risk, a risk of rehospitalization) to a subject. The methods comprise performing one or more assays that detect one or more biomarkers selected from the group consisting of WAP4C, ESAM, LTBR, Mesothelin, and Syndecan-1 performed on a body fluid sample obtained from a subject, and assigning diagnosis or risk based, at least in part, on the result(s) obtained thereby.

Methods and compositions for diagnosis and risk prediction in heart failure

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Cardiff, CA, United States of America

Vance Wong