Smithkline Beecham Corporation

Vance J Novack

Graham R Geen

Neil Smith

Graham Johnson

Inderjit S Mann

Robert John Mills

Neal Ward

Ann Marie Diederich

Ann Marie Eldridge

John Christopher Hanson

This invention relates to a method for preparing 4-substituted-4-cyanocyclohexane carboxylates by forming the cyclohexane ring by treating a &agr;,&agr;-bis(2-haloethyl)-4-benzeneacetonitrile with a dialkyl malonate and decarboxylating the resulting diester.

Method for preparing cyclohexane carboxylic acids

Process for preparing benzopyran compounds

This invention comprises a process for preparing benzopyran derivatives represented by formula (I) ##STR1## in which, R.sup.1 is C.sub.1-20 alkyl, C.sub.2-20 alkenyl, C.sub.2-20 alkynyl, or a group of structure (i), (ii) or (iii). ##STR2##

A process for preparing substituted benzopyran derivatives which comprises a final step cyclisation of the corresponding open-chain intermediates.

Process for preparing tetrazol-5-yl substituted benzopyran compounds

Process for preparing tetrazole-5-carboxylic acid derivatives

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Devon, PA, United States of America

Vance J Novack