Nerviano Medical Sciences S.r.l.

Valter Domenico Croci

Enrico Pesenti

Italo Beria

Dario Ballinari

Marina Ciomei

Barbara Valsasina

Antonella Ciavolella

Juergen Moll

Aurelio Marsiglio

The present invention provides a combination comprising (a) a compound of formula (I) and (b) one or more antineoplastic agents selected from the group consisting of an antimetabolite agent, analkylating or alkylating-like agent, an intercalating agent, a topoisomerase I or II inhibitor, an antimitotic agent, a kinase inhibitor, a proteasome inhibitor and an antibody inhibiting a growth factor or its receptor, wherein active ingredients of the combination are present in each case in free form or in the form of a pharmaceutically acceptable salt or any hydrate or solvate thereof, useful in the treatment of tumors. 

Therapeutic combination comprising a PLK1 inhibitor and an antineoplastic agent

The present invention provides a therapeutic combination comprising (a) a compound of formula (I) as set forth in the specification and (b) one or more antineoplastic agents selected from the group consisting of alkylating or alkylating-like agents, antimetabolite agents and topoisomerase I inhibitors, wherein the active ingredients are present in each case in free form or in the form of a pharmaceutically acceptable salt or any hydrate thereof. 

Therapeutic combination comprising a CDKS inhibitor and an antineoplastic agent

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Nerviano, Italy

Valter Domenico Croci