Research Development Foundation

Other

Valsala Haridas

Jordan U Gutterman

Peter C Michels

Yuri L Khmelnitsky

Vadim M Mozhaev

Disclosed herein are novel oxetane derivatives of avicin D, including compounds of the formula (I), wherein the variables are defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising these derivative compounds. Methods and intermediates useful for making the derivatives, and methods of using the derivatives and compositions thereof, including for the treatment of cancer, are also provided.

Derivatives of avicin D and methods of making and using thereof

The invention provides novel saponin mixtures and compounds which are isolated from the speciesand methods for their use. These compounds may contain a triterpene moiety, such as acacic or oleanolic acid, to which oligosaccharides and monoterpenoid moieties are attached. The mixtures and compounds have properties related to the regulation of apoptosis and cytotoxicity of cells and exhibit potent anti-tumor effects against a variety of tumor cells.

Triterpene compositions and methods for use thereof

The invention provides novel saponin mixtures and compounds which are isolated from the species and methods for their use. These compounds may contain a triterpene moiety, such as acacic or oleanolic acid, to which oligosaccharides and monoterpenoid moieties are attached. The mixtures and compounds have properties related to the regulation of apoptosis and cytotoxicity of cells and exhibit potent anti-tumor effects against a variety of tumor cells.

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Houston, TX, United States of America

Valsala Haridas