Anticancer, Inc.

Valeryi Lishko

Lingna Li

Yuying Tan

Mingxu Xu

Qinghong Han

Huiyan Guo

The present invention describes a method for targeted and specific delivery of beneficial compounds, including hair dyes, melanin, proteins, and nucleic acids for gene therapy, to hair follicle cells using liposomes encapsulating the beneficial compound. Particularly preferred methods describe delivery of hair dyes, melanin or tyrosinase to the hair follicle for the purpose of improving hair color or condition, the delivery of compounds which prevent alopecia or stimulate hair growth, either by encapsulating a compound in liposomes, or by encapsulating a nucleic acid capable of expressing a protein in liposomes. Also described are liposome compositions for practicing the methods.

Method for promoting hair growth

The invention provides a method to provide hair growth by stimulating extrusion of hair from a hair follicle which employs a liposomal formulation of an active ingredient which stimulates extrusion when taken up by the hair follicles.

Method to provide for production of hair coloring pigments in hair follicles

The present invention provides a method to specifically target hair follicles with formulations which effect the production of hair coloring pigments in the follicle. Liposomal formulations for this purpose are disclosed.

Method to provide for production of hair coloring pigments in hair

The invention provides methods to deliver macromolecules to hair follicles selectively using formulations of these macromolecules in liposomal separations.

Methods to deliver macromolecules to hair follicles

The invention describes a method to deliver a composition selectively to hair follicles using a liposomal formulation. Proteins which are cell cycle inhibitors are products of the multi-drug resistance gene or the recombinant materials for their production are targeted to hair follicles by encapsulating them in liposomes.

Method to deliver compositions conferring resistance to alopecia to hair

The present invention provides methods for treating and reducing the potential for cardiovascular disease using methioninase compositions having less than 10 ng endotoxin per mg methioninase.

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Shaker Hts., OH, United States of America

Valeryi Lishko