Netbio, Inc.

Ande Corporation

Valery Leonidovich Bogdanov

Eugene Tan

Gregory John Kellogg

Richard F Selden

John A Wright

Heung Chuan Lam

Ulrich Hans Thomann

Hans Thomann Ulrich

The present disclosure provides fully integrated microfluidic systems to perform nucleic acid analysis. These processes include sample collection, nucleic acid extraction and purification, amplification, sequencing, and separation and detection. The present disclosure also provides optical detection systems and methods for separation and detection of biological molecules. In particular, the various aspects of the invention enable the simultaneous separation and detection of a plurality of biological molecules, typically fluorescent dye-labeled nucleic acids, within one or a plurality of microfluidic chambers or channels. The nucleic acids can be labeled with at least 6 dyes, each having a unique peak emission wavelength. The present systems and methods are particularly useful for DNA fragment sizing applications such as human identification by genetic fingerprinting and DNA sequencing applications such as clinical diagnostics.

Integrated nucleic acid analysis

Integrated systems for the multiplexed amplification and detection of six and greater dye labeled fragments

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Woburn, MA, United States of America

Valery Leonidovich Bogdanov