Vasgene Therapeutics, Inc

Other

Vasgene Theapeutics, Inc

Valery Krasnoperov

Parkash S Gill

Sergey Zozulya

Nathalie Kertesz

Ramachandra Reddy

Timothy David Jones

Francis J Carr

Francis Joseph Carr

Ren Liu

Simon William Keen

Parkash Gill

In certain embodiments, this present invention provides polypeptide compositions, including compositions containing a modified polypeptide, and methods for inhibiting Ephrin B2 or EphB4 activity. In other embodiments, the present invention provides methods and compositions for treating cancer or for treating angiogenesis-associated diseases.

Polypeptide compounds for inhibiting angiogenesis and tumor growth

In certain embodiments, this present invention provides polypeptide compositions (e.g., antibodies and antigen binding portions thereof that bind to EphB4), and methods for inhibiting EphB4 activity. In other embodiments, the present invention provides methods and compositions for treating cancer or for treating angiogenesis-associated diseases.

In certain embodiments, this application provides humanized antibodies that bind to the EphB4 protein as well as uses of the antibodies for therapeutic purposes.

Cancer treatment using humanized antibodies that bind to EphB4

In certain embodiments, this present invention provides polypeptide compositions, and methods for inhibiting Ephrin B2 or EphB4 activity. In other embodiments, the present invention provides methods and compositions for treating cancer or for treating angiogenesis-associated diseases.

In certain embodiments, this present invention provides methods of identifying and using antibodies that act as either agonists or antagonists of Delta-like 4 (Dll4) signaling.

Growing community of inventors

South Pasadena, CA, United States of America

Valery Krasnoperov