Caris Science, Inc.

Arizona State University

Caris Life Sciences Switzerland Holdings Gmbh

Valeriy Domenyuk

David Spetzler

Tassilo Hornung

Stephen Albert Johnston

Mark Miglarese

Chris Diehnelt

Heather O'Neill

David D Halbert

Nianqing Xiao

Frank Schafer

Günter Mayer

Michael Famulok

Nidhi Gupta

Christopher W Diehnelt

Zhan-Gong Zhao

Zhenyu Zhong

Adam Stark

Nick Xiao

David Halbert

Methods and compositions are provided to identify oligonucleotides that bind targets of interest. The targets include tissues, cells, circulating biomarkers such as microvesicles, including those derived from various diseases. The oligonucleotides can be used in diagnostic and therapeutic applications.

Oligonucleotide probes and uses thereof

Methods and compositions are provided for specific aptamers and aptamer pools that bind biomarkers of interest such as microvesicle surface antigens or functional fragments of microvesicle surface antigens. In various embodiments, aptamers of the invention are used in diagnostic, prognostic, or theranostic processes to screen a biological sample for the presence or levels of biomarkers such as microvesicles that are determined to provide a diagnostic, prognostic, or theranostic readout. The diagnosis, prognosis, or theranosis may be related to cancer or other diseases and disorders. The invention also provides methods and composition to facilitate aptamer library screening and aptamer detection methods.

Aptamers and uses thereof

Composition of synbodies that bind influenza. The synbodies are composed of two peptides joined on a scaffold.

High affinity synbodies for influenza

Methods are provided for selecting aptamers that are specific to a target of interest from amongst a library of potential aptamer sequences. Aptamers disclosed can be used to detect and/or characterize biological entities of interest, e.g. microvesicles and/or surface antigens. Further disclosed are biomarkers that can be used for diagnosing different disorders including different types of cancer.

Compositions and methods for aptamer screening

The invention provides methods for identifying cell binding and/or lytic polypeptides that permit production of specific polypeptide therapeutics in a high throughput manner.

High throughput selection of specific cell binding and lytic polypeptides

The present invention provides polypeptides, compositions thereof, and methods for use of the polypeptides in treating bacterial infection and for use as disinfectants.

Anti-bacterial polypeptides and pathogen specific synthetic antibodies

Growing community of inventors

Tempe, AZ, United States of America

Valeriy Domenyuk