Sclavo Spa

Snamprogetti S.p.a.

Enichem Elastomeri S.p.a.

Menarini Ricerche S.p.a.

Sclano S.p.a.

Valerio Caciagli

Antonio S Verdini

Carlo Alberto Maggi

Vincenzo Politi

Giovanna De Luca

Giovanni Di Stazio

Alessandro Sisto

Luciano Re

Danilo Giannotti

Alessandro Giolitti

Maria Altamura

Valentina Fedi

Nicholas Harmat

Rossano Nannicini

Franco Pasqui

Antonio Guidi

Described herein are compounds of formula (I) useful as antagonists of tachykinins in general, and in particular of neurokinin A; and the pharmaceutical formulations comprising the compounds of formula (I) 

Linear basic compounds having NK-2 antagonist activity and formulations thereof

An improvement is described in the synthesis method for N.sup..alpha. -trityl-N.sup.G -trityl arginine within a process for preparing N.sup..alpha. -fluorenylmethoxycarbonyl-N.sup.G -trityl-arginine from arginine, comprising:

Process for the synthesis of N.sup..alpha.

A method is described for substituting at least one hydrogen atom originally present in the guanidino group of a compound of general formula (I) ##STR1## where R is any substituted or unsubstituted residue, by a group R.sub.1 where R.sub.1 is an unsubstituted or substituted, linear or branched alkyl, consisting of:

Method for alkylating guanidino groups

An improvement is described in the synthesis method for N.sup..alpha. -trityl-N.sup.G -trityl arginine within a process for preparing N.sup..alpha. -fluorenyl-methoxycarbonyl-N.sup.G -trityl-arginine from arginine, comprising:

New decapeptides having hypotensive action are disclosed, which can be defined by the formula:

Decapeptides having hypotensive action and process for their preparation

A dioldione represented by the formula: ##STR1## in which R.sup.1, R.sup.2, R.sup.3, R.sup.4, the same or different, represent alkyl, cycloalkyl, arylalkyl, aryl or hydrogen, is prepared by reacting a compound represented by the formula: ##STR2## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4 have the above meanings, with an oxidizing mixture consisting of osmium tetroxide and an alkali or alkali-earth metal chlorate.

Process for the preparation of dioldiones

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Rome, Italy

Valerio Caciagli