Wyeth Holdings Corporation

Valerie Sue Bernan

Haiyin He

Mark Edward Ruppen

Jason Arnold Lotvin

Michael Greenstein

Darren Robert Abbanat

Arthur Bailey

Alan Gordon Sutherland

Phaik-Eng Sum

Russell Dushin

Edmund Graziani

Howard Hancock Newman

Subas Man Sakya

Ping Cai

Hui Yu Yang

FangMing Kong

Bo Shen

Scott William Luckman

Stanley Albert Lang

Ting-Zhong Wang

Arthur Emery Bailey

Russell George Dushin

This invention relates to a new antibiotic designated P175-A, to production of fermentation ofNRRL 30633, to methods for recovery and concentration from the crude solutions, and to a process for purification and to semisynthetic esters and ethers of P175-A.

Antibiotic P175-A and semisynthetic derivatives thereof

The disclosure describes the production of anticancer agent LL-D45042, having the structure:by fermentation, to methods for the recovery and concentration of this anticancer agent from crude solutions, and to processes for the purification of this anticancer agent as well as a new microorganism of the speciesLL-D45042 and mutants thereof useful in the preparation of this compound.

Process for producing anticancer agent LL-D45042

The invention provides compounds of formulaWherein R, R, R, R, R, R, R, R, R, Rand Rare defined in the specification. These compounds are useful as antibiotic agents.

Glycopeptide antibiotics

Growing community of inventors

New City, NY, United States of America

Valerie Sue Bernan