Bioalliance Pharma

Centre National De La Recherche Scientifique

Onxeo S.a.

Ens Cachan

Valérie Polard

Christian Auclair

Christine Chaumont

Frédéric Subra

Andrei Maksimenko

Emilia Pisani

Christelle Pragnon

Sophie Lebel-Binay

Malam Aboubakar

The invention relates to new therapeutic approaches for treating cancer, in particular hepatocellular carcinoma, with Nanoparticules loaded with a chemotherapeutic antitumoral agent. In particular, it relates to the treatment of cancer by administration of said Nanoparticules by intravenous infusion for at least 2 hours in order to prevent toxicological side effects and increase the benefit/risk ratio of the treatment.

Nanoparticles loaded with chemotherapeutic antitumoral drug

A vectorization and delivery system of therapeutic or diagnostic substances including (i) at least one polymer and (ii) at least one nontoxic positively charged polysaccharide, the nanoparticles having a substantially homogeneous distribution of size.

Vectorization system comprising nanoparticles of homogenous size of at least one polymer and at least one positively charged polysaccharide and method for the preparation thereof

The invention concerns a method for analyzing tumor agressivity of cancer cells comprising measurement of the amount of stationary polymerized actin in a lysate of said cells. Advantageously, the measurement of the amount of stationary actin is carried out by fluorescence static polarization.

Method for analyzing tumor aggressivity comprising measurement of polymerized actin

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Alfortville, France

Valérie Polard