Julius-Maximillians-Universität-Würzburg

Julius-mazimillians-universitat Wurzburg, a German University

Julius-maximillians-universitat Wurzburg, a Germany University

Julius-maximilians-universtitat-wurzburg

Julius-maximilians-universitat Wurzburg

Valérie Jahns

Martin Lohse

Roland Jahns

Dieter Palm

Viacheslav Nikolaev

Martin J Lohse

The present invention relates to novel &#x3b2;-AR homologous cyclopeptide-mutants comprising only two cysteine residues able to form an intramolecular linkage, to linear peptides that can form these cyclopeptide-mutants and to nucleic acid molecules encoding these cyclopeptide-mutants and linear peptides. Moreover, vectors and recombinant host cells comprising said nucleic acid molecule and a method for producing the disclosed cyclopeptide-mutants are provided. Further provided is a composition comprising the peptides, nucleic acid molecules, vectors or host cells of the invention. The present invention also relates to therapeutic and diagnostic means, methods and uses taking advantage of the peptides of the invention and to means, methods and uses for detecting anti-&#x3b2;-adrenergic receptor antibodies like anti-&#x3b2;-adrenergic receptor antibodies.

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Embodiments of the present invention provide for novel peptides of use for detection and/or inhibition of anti-&#x3b2;1-adrenergic receptor antibodies. Certain embodiments concern uses of cyclic and/or linear peptides. In other embodiments, the present invention relates to novel peptides of use in diagnostic and/or pharmaceutical compositions. Some embodiments concern diagnosing and/or treating cardiac conditions. Cardiac conditions of the instant invention can concern infectious heart disease, non-infectious heart disease, ischemic heart disease, non-ischemic heart disease, inflammatory heart disease, myocarditis, cardiac dilatation, idiopathic cardiomyopathy, idiopathic dilated cardiomyopathy, immune-cardiomyopathy, heart failure, and any cardiac arrhythmia condition.

Means for the inhibition of anti-&#x3b2;1-adrenergic receptor antibodies

Means for the inhibition of anti-beta1-adrenergic receptor antibodies

Growing community of inventors

Würzburg, Germany

Valérie Jahns