Esbatech, an Alcon Biomedical Research Unit LLC

Valerie Hulmann-Cottier

David M Urech

Esther Furrer

The invention provides methods for identifying immunobinders, such as scFv antibodies, capable of specifically binding to cell surface antigens, and compositions identified according to said methods.

Humanized immunobinders of cell-surface antigens

Methods for producing immunobinders of cell-surface antigens

The invention provides compositions and methods that enhance the delivery of large macromolecules (i.e., greater than 10 kDa), such as antigen-binding polypeptides, across tight junctions. Such methods and compositions are particularly useful for delivering therapeutic antigen-binding polypeptides to the CNS, via intranasal administration, for the treatment of neurological disorders.

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Zurich, Switzerland

Valerie Hulmann-Cottier