Centre National De La Recherche Scientifique

Bioalliance Pharma Sa

Statlife

Valérie Helin

Andrei Maksimenko

Marina Gottikh

Stéphane Ragusa

Calude Malvy

The present invention relates to a computer-implemented method for classification of a picture to be analyzed, by attribution of a grade thereto, comprising: a) determining the distance between the picture to be analyzed and pictures from a database of graded pictures; b) selecting from within the database of graded pictures a predetermined number of the closest neighboring pictures or neighboring pictures which are at a distance from the picture to be analyzed below a threshold; c) determining the mean of the grades of the selected neighboring pictures; d) attributing the mean grade to the picture to be analyzed; and e) displaying the mean grade attributed to the picture to be analyzed on an output device.

Computer-implemented method for classification of a picture

Oligonucleotides capable of modifying or inhibiting in vivo or in vitro expression of a target gene wherein the oligonucleotide has an antisense sequence, at least one secondary structure, and optionally a supplementary nucleotide sequence located at one and/or both ends of the antisense sequence and wherein the secondary structure disintegrates upon attachment of the oligonucleotide to a target nucleic acid; a pharmaceutical composition containing such an oligonucleotide as an active ingredient; and a method of treatment using such an oligonucleotide.

Oligonucleotides containing an antisense sequence stabilized by a secondary structure, pharmaceutical compositions containing them and method of blocking gene expression using them

Growing community of inventors

Paris, France

Valérie Helin