Metabrain Research

Merck Patent Gesellschaft MIT Beschrankter Haftung

Valerie Autier

Micheline R Kergoat

Christine G Charon

Franck F Lepifre

Annick Audet

Sophie N Raynal

Gersande R Lena

Annick M Audet

Gérard Moinet

Jean-Denis Durand

Annick Arbellot De Vacqueur

Lauren R Faveriel

Dominique Mariais

Catherine Kargar

This invention relates to oxime and alkoxy derivatives of the general formula (I), or an enantiomer, diastereoisomer, hydrate, solvate, tautomer, racemic mixture or pharmaceutically acceptable salt thereof for use as a medicament for the treatment and/or prevention of muscle atrophy in mammals and/or for limiting muscular atrophy in mammals and/or to promote muscle growth in exercising mammals aimed at increasing muscle mass and quality, preventing the occurrence of symptoms of sarcopenia related to age or rehabilitation after a muscle loss, age-related muscle atrophy and/or the consequences of drug therapy and/or immobilization and/or cachexia.

Derivatives used in the treatment of muscle atrophy

The present invention relates to a thiophene derivative of the following general formula I or an enantiomer, diastereoisomer, hydrate, solvate, tautomer, racemic mixture or pharmaceutically acceptable salt thereof or to its use as a drug in particular intended for treating and/or preventing diabetes, its complications and/or associated pathologies, advantageously diabetes of type II and hyperglycemia.

Useful thiophene derivatives in the treatment of diabetes

The present invention relates to imidazopyridine derivatives of the following general formula I: and to their use as a drug, in particular in treating and/or preventing diabetes, its complications and/or associated pathologies.

Imidazopyridine derivatives useful in treating diabetes

The present invention relates to the use of at least one compound with inhibitory activity on kynurenine 3-hydroxylase for the preparation of a medicament for the prevention and/or treatment of diabetes.

Kynurenine 3-hydroxylase inhibitors for the treatment of diabetes

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Gif sur Yvette, France

Valerie Autier