Adir Et Compagnie

Valerie Audinot

Mark Millan

Jean-Louis Peglion

Bertrand Goument

Joel Vian

Jean-Christophe P Harmange

Aimee Dessinges

Gilbert Lavielle

Jean-Charles Schwartz

Alex Cordi

Olivier Muller

Jean-Michel Lacoste

Alain Gobert

Mauricette Brocco

Pierre Sokoloff

New N-arylpiperidine compounds of formula: ##STR1## wherein: A, m, R, E, n and Ar are as defined in the description, the isomers thereof and the addition salts thereof with a pharmaceutically acceptable acid, and medicinal products containing the same are useful in the treatment of disorders involving the serotininergic system.

N-aryl piperidine compounds as 5HT.sub.1B antagonists

Compounds of formula: ##STR1## wherein: A, m, n, E and Y are as defined in the description, the optical isomers thereof and the physiologically-tolerable salts thereof. These compounds, their optical isomers and their physiologically-tolerable salts, can be used as medicaments in the treatment of psychotic disorders, anxio-depressive disorders, and aggressiveness.

3-(piperid-4-yl)-1,2-benzisoxazole and

New compounds of formula: ##STR1## wherein: A--D--E, X, n and R are as defined in the description, in racemic form and in the form of optical isomers, and their addition salts with pharmaceutically acceptable acids. Those compounds may be used as medicaments.

Tetracyclic 1,4-oxazine compounds

New compounds of formula: ##STR1## wherein: --A--D--E, X, n, Y and Z are as defined in the description, in racemic form and in the form of optical isomers,

Heterocyclic tertiary amines

Compound of formula (I): ##STR1## in which: R.sub.1 represents hydrogen, halogen, alkyl, alkoxy, trihalomethyl or hydroxyl,

Indole, indazole and benzisoxazole compounds

Compound of formula (I): ##STR1## and its addition salts with a pharmaceutically acceptable acid or base, a medicinal products containing the same are useful as partial agonist of the glycine B site.

4-imidazolidinone compound

New compounds of formula: ##STR1## wherein A-B, X, Y, R and n are as defined in the description. The geometric isomers, racemate and optical isomers thereof and the addition salts with pharmaceutically acceptable acids, and medicinal products containing the same are useful for treating psychotic disorders, depression, Parkinson's disease, memory disorders and disorders associated with drug abuse.

Tetracyclic piperidine and 1,4-oxazine compounds

New compounds of formula: ##STR1## wherein: A-B, n and Y are as defined in the description, their optical isomers and physiologically tolerable salts thereof with appropriate acids. The products of the invention may be used as medicaments.

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Poissy, France

Valerie Audinot