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Institut Organicheskoi Khimii Akademii Nauk Ukrainskoi Ssr

Institut Organischskogo Sinteza Akademii Nauk Ssr

Valeria V Kastron

Gunar Y Dubur

Rasma O Vitolin

Lev Moiseevich Yagupolsky

Agris A Kimenis

Natalya V Kondratenko

Vladimir I Popov

Alexandr A Kolomeitsev

Edmund Y Lukevits

Jury A Fialkov

Svetlana V Shelyazhenko

Guntis V Zarinsh

Marita Y Selga

Elena L Khanina

Nikolai P Erchak

Indulis P Skrastinsh

2,6-dimethyl-3,5-dimethoxycarbonyl-4-(5'-tri

The present invention relates to organic chemistry. The novel compound 2-oxo-4-(2'-difluoromethylthiophenyl)-5-methoxycarbonyl-6-methyl-1,2,3,4-t etrahydropyrimidine has the formula: ##STR1## Said compound displays coronary-dilating activity and can be utilized in medicine.

2-oxo-4-(2'-difl

The present invention relates to derivatives of 1,4-dihydropyridine and, more specifically, to 2,6-dimethyl-3,5-dicarbomethoxy-4-(o-difluoromethylthiophenyl)-1,4-dihydro pyridine having the formula ##STR1## The proposed compound features pronounced hypotensive activity of prolonged duration and is capable of producing a coronarodilating effect while having low toxicity and being useful for treating diseases of the cardiovascular system.

2,6-Dimethyl-3,5-dicarbomethoxy-4-(ortho

The present invention relates to derivatives of 1,4-dihydropyridine and, more specifically, to 2,6-dimethyl-3,5-dimethoxycarbonyl-4-(o-difluoromethoxyphenyl)-1,4-dihydro pyridine of the formula: ##STR1## This compound features a clearly pronounced hypotensive activity while being low-toxic, wherefore it can be used in medicine for treating hypertensive disease.

2,6-Dimethyl-3,5-dimethoxycarbonyl-4-(ortho-difluoromethoxyphenyl)-1,4-di

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Valeria V Kastron