Pfizer Italia S.r.l.

Nerviano Medical Sciences S.r.l.

Valeria Pittala′

Daniele Fancelli

Mario Varasi

Simona Bindi

Roberto Tonani

Matteo D'Anello

Bicyclo-pyrazole compounds of formula (I), as herein defined, are useful for treating diseases linked to disregulated protein kinases.

Bicyclo-pyrazoles and pharmaceutical compositions comprising them

Bicyclo-pyrazole compound of formula (I) and pharmaceutically acceptable salts thereof, as defined in the specification, processes for their preparation, combinatorial libraries comprising a plurality of them and pharmaceutical compositions thereof, are herewith disclosed: the compounds of the invention are useful, in therapy, as protein kinase inhibitors, for instance in the treatment of cancer.

Condensed heterocyclic pyrazole derivatives as kinase inhibitors

Bicyclo-pyrazoles of formula (I) as defined in the specification, and pharmaceutically acceptable salts thereof, process for their preparation and pharmaceutical compositions comprising them are disclosed; the compounds of the invention may be useful, in therapy, in the treatment of diseases associated with a disregulated protein kinase activity, like cancer.

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Catania, Italy

Valeria Pittala′