Mcgill University

Universita′ Degli Studi Di Milano

Università Degli Studi Di Parma

Universita Degli Studi Di Urbino

Fraschini, Franco

Gobbi, Gabriella

Valeria Lucini

Marco Mor

Giorgio Tarzia

Franco Fraschini

Gilberto Spadoni

Silvia Rivara

Gabriella Gobbi

Annalida Bedini

Novel melatonin ligands of Formula I: or pharmaceutically acceptable salts thereof wherein: n is 1 or 2; m is 0, 1 or 2; p is 0, 1, 2, 3, 4, 5, 6, 7 or 8; v is 2 or 3; A is aryl or heteroaryl; Z is O, S or NR; Y is selected from the group consisting of hydrogen, aryl, heteroaryl, C-Calkyl, C-Ccycloalkyl, and R is selected from the group consisting of hydrogen, hydroxyl, &#x2014;OCF, CF, C-Calkyl, C-Calkyloxy, C-Calkylthio, halogen and &#x2014;Z&#x2014;(CH)-A; Ris selected from the group consisting of C-Calkyl, C-Ccycloalkyl, CF, hydroxy-substituted C-Calkyl, hydroxy-substituted C-Ccycloalkyl, and NHR, wherein Ris C-Calkyl or C-Ccycloalkyl; Ris selected from the group consisting of: hydrogen, C-Calkyl, C-Calkyloxy, OCF, CF, hydroxyl, and halogen; Ris selected from the group consisting of hydrogen, C-Calkyl, C-Calkyloxy, OCF, CF, hydroxyl, and halogen; R and Rmay be connected together to form an &#x2014;O&#x2014;(CH)bridge representing with the carbon atoms to which they are attached a 5- or 6-membered heterocyclic ring system; Ris selected from the group consisting of hydrogen, C-Calkyl, C-Calkyloxy, OCF, CF, hydroxyl, and halogen; Ris selected from the group consisting of hydrogen and C-Calkyl; Ris selected from the group consisting of hydrogen, C-Calkyl, C-Calkyloxy, OCF, CF, hydroxyl, and halogen; and Ris selected from the group consisting of hydrogen and C-Calkyl.

Melatonin ligands having antidepressant activity as well as sleep inducing properties

Growing community of inventors

Milan, Italy

Valeria Lucini