Ionwerks, Inc.

Valeri V Raznikov

J Albert Schultz

Thomas F Egan

Michael V Ugarov

Agnès Tempez

Marc Gonin

Katrin Fuhrer

Michael I McCully

Vladislav V Zelenov

Agnes Tempez

Gennadiy Savenkov

Marina O Raznikova

Valentin A Tarasenko

Albert J Schultz

The content of the invention comprises a concept of multi-beam ion pre-selection from a single sample, coordinated mobility (against the gas flow) separation, cooling ions in supersonic gas flow and mass separation of thus low divergent ions by single or plural compact high-resolution orthogonal time-of-flight mass spectrometers both linear or reflectron type with controlled collision-induced dissociation (CID) and multi-channel data recording for the optimization of sample use in the analysis, and obtaining as much useful information about the sample as possible in a reasonably short time.

Multi-beam ion mobility time-of-flight mass spectrometry with multi-channel data recording

The present invention relates generally to instrumentation and methodology for the characterization of chemical samples in solutions or on a surface which is based on modified ionization methods with or without adjustable pH and controllable H-D exchange in solution, in improved ion mobility spectrometer (IMS), a multi-beam ion per-selection of the initial flow, and coordinated mobility and mass ion separation and detection using a single or several independent time-of-flight mass spectrometers for different beams with methods for fragmenting ion mobility-separated ions and multi-channel data recording.

Multi-beam ion mobility time-of-flight mass spectrometer with bipolar ion extraction and zwitterion detection

A detection scheme for time-of-flight mass spectrometers is described that extends the dynamic range of spectrometers that use counting techniques while avoiding the problems of crosstalk. It is well known that a multiple anode detector capable of detecting different fractions of the incoming particles may be used to increase the dynamic range of a TOFMS system. However, crosstalk between the anodes limits the amount by which the dynamic range may be increased. The present invention overcomes limitations imposed by crosstalk by using either a secondary amplification stage or by using different primary amplification stages.

Multi-anode detector with increased dynamic range for time-of-flight mass spectrometers with counting data acquisitions

Improved ion focusing for an ion mobility drift cell allows for improved throughput for subsequent detection such as mass detection. Improved focusing is realized by the use of alternating regions of high and low electric fields in the ion mobility drift cell.

Ion mobility TOF/MALDI/MS using drift cell alternating high and low electrical field regions

Multi-anode detector with increased dynamic range for time-of-flight mass spectrometers with counting data acquisition

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Moscow, Russia

Valeri V Raznikov