Koninklijke Philips Corporation N.v.

Valentina Lavezzo

Cornelis Petrus Hendriks

Murtaza Bulut

Lieke Gertruda Elisabeth Cox

Mark Thomas Johnson

Daan Anton Van Den Ende

Roland Alexander Van De Molengraaf

Marco Baragona

Milica Kovacevic Milivojevic

Eduard Gerard Marie Pelssers

Bart Gottenbos

Franciscus Johannes Gerardus Hakkens

Yu-Wen Chang

Cornelis Reinder Ronda

Steven Charles Deane

Nigel David Young

Sergei Shulepov

Herbert Lifka

Paulus Cornelis Duineveld

Johannes Hendrikus Maria Spruit

Olaf Thomas Johan Antonie Vermeulen

Denny Mathew

Adrianus Wilhelmus Dionisius Maria Van Den Bijgaart

Peter Coops

Raymond Van Ee

Marinus Karel Johannes De Jager

Gertrude Riëtte Bakker-Van Der Kamp

Hernán Guillermo Morales Varela

James Donald Gwyer

Zeynep Sabah

Quintin Oliver Williams

Rene Leonardus Jacobus Marie Ubachs

Milica Kovacevic-Milivojevic

Maaike Cornelia Johanna Wilhelmina Van Hulten

Lucas Scheffers

Sandra Hoetzl

Guido Antonius Theodorus Adriaensen

Lieke Gertrude Elisabeth Cox

Sandra Hotzl

Vinod Reddy Challa

Anandh Balakrishnan

Tianyi Wang

An Nguyen

Bruno Jean François Frackowiak

Sandra HÖTZL

Adrianus Wilhelmus Dionisius M Van Den Bijgaart

Jason Daniel Miller

Bjorn Stemkens

A method of developing a personalized digital model of an anatomy of a person by a computer system comprising a processor arrangement and a communication module. The processor arrangement receives input data on an actual physical condition of the person from the communication module; searches a database of digital models modelling different physical conditions and selects a digital model from said database that closely matches the actual physical condition of the person based on some received input data; personalizes the selected digital model by developing the modelled physical condition of the selected digital model with a physiological development model based on received input data such that the developed modelled physical condition closely resembles said actual physical condition; and generates an output of the personalized digital model of said person on a data storage medium. Also disclosed, a computer program product and computer system for implementing the method.

Digital twin of a person

A system for predicting the onset of a physiological condition of a subject combines an in-vitro subject model having input parameters relating to actual or predicted external stimuli to which the subject is or may be exposed and an in-silico model. The in-vitro model outputs subject-specific parameters which are not being monitored, or cannot be monitored, in-vivo. The in-silico subject model uses subject-specific parameters to predict the response of the subject to the actual or predicted external stimuli and thereby predict an onset of a physiological condition of the subject.

Predicting the onset of a physiological condition of a subject using a digital biophysical model

Embodiments are described herein for training machine learning models using digital twin outputs, including for purposes of pain quantification and estimation. In various embodiments, simulation parameter(s) may be applied to a digital twin created for a subject. The digital twin may simulate an anatomical structure of the subject, and the simulation parameter(s) may cause the digital twin to generate digital twin output that simulates behavior of the anatomical structure in response to the one or more simulation parameters. Data indicative of the digital twin output may be applied as input across a pain estimation machine learning model to generate pain estimation output. Based on the pain estimation output, a quantification of pain, e.g., an estimated pain score, may be rendered using an output device and/or used to select a treatment plan.

Quantification and estimation based on digital twin output

A computer system is disclosed comprising a processor arrangement communicatively coupled to a data storage arrangement storing a digital model of a section of a lumen system of a patient; and a communication module communicatively coupled to said processor arrangement and arranged to receive sensor data pertaining to an internal parameter of said lumen system from a sensor within said section of the lumen system. The processor arrangement is arranged to receive said sensor data from the communication module; retrieve said digital model from the data storage arrangement; simulate an actual physical condition of said lumen system by developing said digital model based on the received sensor data; and generate an output relating to said simulated actual physical condition for updating an electronic device. Also disclosed is a method of monitoring a patient with such a computer system, a computer program product for implementing such a method and a patient monitoring system.

Patient lumen system monitoring

Disclosed is a method () of providing a personalized parameter model of at least part of the physiology of a person () carrying a set of sensors () with a computer system () comprising a processor arrangement () for the purpose of updating a biophysical model or digital twin of the person. The method comprises, with said processor arrangement, receiving () sensor data from said set of sensors with the communication interface over a defined period of time, the sensor data from each sensor representing a parameter relevant to an actual physiological state of the person; evaluating () the received sensor data from each sensor to define the personalized parameter model (), said model including the evaluated dynamic behaviour of the values of each parameter observed with said sensors over the defined period of time and providing () the defined personalized parameter model for updating a digital model () of at least part of the anatomy of said person. Also disclosed is a method () for updating such a digital twin in which the digital twin is updated using such a personalized parameter model. In addition, a computer program product for implementing such methods and a computer system () implementing such methods are also disclosed.

Digital twin updating

The invention relates to a mouthpiece for performing a treatment of teeth such as teeth whitening. Accordingly, the mouthpiece may be arranged for cosmetic treatment. The treatment is based on illumination of the teeth of light with a suitable wavelength. The mouthpiece is designed so that light from light sources, e.g. LED's, is sufficiently homogenized so that the light irradiance at the teeth is sufficiently uniform to achieve good treatment results. Furthermore, the mouthpiece is designed so that the irradiance at the teeth is sufficiently high to achieve efficient treatment and so that heating of the teeth is minimized to an acceptable heating.

Mouthpiece for dental treatment

An actuator or sensor device comprises an electroactive polymer (EAP) arrangement which extends between fixed opposite ends. The electroactive polymer arrangement comprises a passive carrier layer and an active electroactive polymer layer, wherein at or adjacent the ends, the passive carrier layer and the active EAP layer are mounted with one over the other in a first order, and at a middle area between the ends, the carrier layer and the active EAP layer are mounted in an opposite order. This enables internal stresses and moments within the electroactive polymer arrangement to be used more effectively to contribute to displacement or actuation force.

Actuator or sensor device based on an electroactive or photoactive polymer

A method and system for determining an amount of risk an air pollutant poses to a subject. A risk level is calculated by determining a dosage of the air pollutant, received by the subject over a predetermined period of time, and obtaining historic information about historic dosages of the air pollutant. The risk level is then calculated using the dosage and the historic information to thereby determine a risk level associated with the accumulated deposition of the air pollutant in the portion of the subject's respiratory tract.

Determining a risk level posed by an air pollutant

A oral irrigator device () for cleaning teeth, including a system () for producing a stream of liquid/air bursts and a nozzle () connected to the system, and through which the stream of liquid/air bursts are directed. The nozzle can include a guidance tip () including a base portion (), a tip portion (), and an orifice () through which the stream of liquid/air bursts exits at a flow output pattern, and a flow output pattern selection mechanism (') connected to or positioned within the guidance tip. A flow output pattern selection mechanism can be configured to be selectively actuated and to vary, upon the actuation the flow output pattern between a first flow output pattern to at least a second flow output pattern.

Adjustable assembly and nozzle for providing various liquid/air output flow patterns

A nozzle () for an oral irrigator device () having a guidance tip () with at least one orifice () at one end, and a nozzle spacer assembly () positioned around the at least one orifice (). The at least one orifice is configured to expel a fluid as one of a jet, a spray, or any combination thereof. The nozzle spacer assembly () comprises at least two pairs of pliable spacers () that extend from the surface () for ensuring that the area at an entrance of an interproximal space between two teeth are treated, and (ii) establishing an improved angle of impact of the fluid expelled from the orifice.

Nozzle for oral irrigator device including a nozzle spacer assembly

An actuator device comprises an EAP structure which deforms in response to a drive signal applied to the device, a device output being derived from movement of the EAP structure. A delay arrangement is used such that the mechanical output from the device is not generated for a first range or type of applied drive signals, and said device output is generated for a second range or type of applied drive signals. This device is for example particularly suitable for use in a passive matrix system.

Actuator device and array of the same

A bending actuator device or sensor device for sensing bending comprises a stack of electroactive polymer units. The adjacent electroactive polymer units in the stack are slidable relatively to each other. This means that, for an actuator for example, an increased actuation force is enabled without requiring increased driving voltage, and it also avoids the problems of stress build up by allowing sliding between the units.

Actuator or sensor device based on an electroactive polymer

An oral cleaning device comprises a body which carries a set of projections. An actuator device is associated with one or more of the projections in the form of an electroactive polymer structure for adjusting a position of the associated one or more projections. This enables dynamic control of the cleaning function.

Oral cleaning device with adjustable shape and oral cleaning method

A nozzle () for an oral irrigator device () having a guidance tip () with an orifice at one end, and a dynamic nozzle actuator () positioned within said guidance tip. The orifice () is configured to expel a fluid as one of a jet, a spray, or any combination thereof. The dynamic nozzle actuator () comprises at least one responsive material adapted for being energized and configured to implement at least one dynamic actuation of an effective channel () for dynamically influencing at least one of (i) a direction of fluid expelled from the orifice (), (ii) an angle of fluid expelled from the orifice (), (iii) a cross-sectional width of fluid expelled from the orifice (), and (iv) any combination thereof.

Nozzle for oral irrigator device including a dynamic nozzle actuator with responsive materials

Attachment assemblies for oral hygiene devices and, in particular, attachment assemblies having improved designs to more effectively clean an individual's tongue or other inter-oral surface are described herein. These improved attachment assembly correspond, amongst other aspects, to improved fluid chamber configurations, improved fluid channel configurations, improved fluid exit hole configurations, improved air inlet hole configuration, and air channel features. Furthermore, these improvements to attachment assemblies are capable of being implemented separately from, or in combination with, one another.

Attachment assemblies for oral hygiene devices having improved fluid chamber, fluid channel, fluid exit hole, air inlet hole, and air channel features

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Heeze, Netherlands

Valentina Lavezzo