Centre National De La Recherche Scientifique

Assistance Publique-hopitaux De Paris

Occlugel

Université Paris Diderot-Paris 7

Universite Paris Diderot-paris

Valentin Verret

Laurence Moine

Alexandre Laurent

Michel Wassef

Laurent Bedouet

Stephanie Louguet

Emeline Servais

The present invention relates to a macromolecule-loaded bioresorbable crosslinked polymer wherein the polymer is obtainable from the polymerization of: (i) at least one monomer of formula (I) (CH&#x2550;CR)CO&#x2014;K wherein: &#x2014;K represents O&#x2014;Z or NH&#x2014;Z, Z representing (CRR)&#x2014;CH, (CH&#x2014;CH&#x2014;O)&#x2014;H, (CH&#x2014;CH&#x2014;O)&#x2014;CH, (CH)&#x2014;NRRwith m representing an integer from 1 to 30; &#x2014;R, R, R, Rand Rindependently represent H or a C1-C6 alkyl; and (ii) at least one bio-resorbable block copolymer cross-linker, and wherein the macromolecule is chosen in the group consisting of proteins and nucleic acids.

Implantable bio-resorbable polymer charged with fragile macromolecules

The present invention relates to a polymer obtained from the polymerization of: (i) at least one monomer of formula (I) (CH&#x2550;CR)CO&#x2014;K (1) wherein: &#x2014;K represents O&#x2014;Z or N H&#x2014;Z, Z representing (CRR)m-CH, (CH&#x2014;CH&#x2014;O)m-H, (CH&#x2014;CH&#x2014;O)m-CH, (CH)m-NRRwith m representing an integer from 1 to 30; &#x2014;R, R, R, Rand Rindependently represent H or a C1-C6 alkyl; (ii) at least between 0.1 and 50% mol, advantageously between 1 and 30% mol, more advantageously between 1 and 20 mol % of a cyclic monomer having a exomethylene group of formula (II) wherein: &#x2014; R6, R7, R8 and R9 represent independently H or a C5-C7 aryl group or R6 and R9 are absent and R7 and R8 form together with the carbon atom on which they are bonded a C5-C7 aryl group; &#x2014;i and j represent independently an integer chosen between 0 and 2; &#x2014;X represents either O or X is not present and in this latter case, CR6R7 and CR8R9 are linked via a single bond C&#x2014;C and (iii) at least one bio-resorbable block copolymer cross-linker. 

Implantable swellable bio-resorbable polymer

Growing community of inventors

Gentilly, France

Valentin Verret