Arzneimittelwerk Dresden Gmbh

Valentin V Lyskovzev

Hildegard Poppe

Reni Bartsch

Dieter Lohmann

Natalja V Kaverina

Helmut Wunderlich

Anna N Grizenko

Aleksandr P Skoldinov

Andreas Stark

Wolfgang Sauer

Alexandr P Skoldinov

Lothar Zenker

Gennadi G Chichkanov

Alwina W Stawrowskaya

Lothar Zenkar

Ekaterina K Grigoreva

Carla Ruger

Arkadij M Lichoserstov

Yekaterina K Grigoryeva

Yekaterina A Talmachova

5-(w-Aminoacyl)-5,10-dihydro-11H-dibenzo(b,e)(1,4)-diazepine-11-ones, and their preparation are disclosed for treatment of antiarrhythmia and as an anticholinergic drug.

5-(1-aminoacyl)-5,10-dihydro-11H-dibenzo[b,e](1,4)diazepin-11-ones

New 3-carbalkoxyamino-5-(alpha-aminopropionyl)-5H-dibenz[b,f]azepines of formula I and their pharmaceutically acceptable salts were found to be suitable actives for the treatment of cardiac arrhythmia. Previously unknown 3-carbalkoxyamino-5-(alpha-halogenpropionyl)-5H-dibenz[b,f]azepines are obtained from 3-carbalkoxyamino-5H-dibenz[b,f]azepines by reaction with alpha-halogenpropionyl halides. Through their reaction with ammonia, primary amines or secondary amines, the new 3-carbalkoxyamino-5-(alpha-aminopropionyl)-5H-dibenz[b,f]azepines are obtained, which can be optionally converted into their pharmaceutically acceptable acid addition salts.

3-carbalkoxyamino-5-(alpha-aminopropionyl)-5H-dibenz[b,f]azepines and

New 3-carbalkoxyamino-5-aminoacyl-5H-dibenz[b,f]azepines and their pharmaceutically acceptable acid addition salts, and methods for their synthesis are described. These compounds are useful as antiarrhythmic agents in the treatment of heart disorders. The new compounds are made by reacting a 3-carbalkoxyamino-5-halogenacyl-5H-dibenz[b,f]azepines with an amine to form the desired target product, which can be optionally converted into its pharmaceutically acceptable acid addition salt.

3-carbalkoxyamino-5-aminoacyl-5H-dibenz[b,f]azepines, and methods for

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Moskau, undefined

Valentin V Lyskovzev