Pharma Mar, S.a.

Valentin Martinez

Ignacio Manzanares

Carmen Cuevas

Simon Munt

Pilar Gallego

Alberto Rodriguez

Maria Flores

Derivatives of Et-743 or Et-770 or Et-729 are provided. The derivatives are of the general formula Ia.: wherein the substituent groups take various permitted meanings.

Antitumoral derivatives of ET-743

Derivatives of ecteinascidin 736 of general formula (I) wherein the groups R, R, R, Rand Rare each independently selected from the group consisting of H, OH, OR', SH, SR&#x2032;, SOR&#x2032;, SOR&#x2032;, C(&#x2550;O)R&#x2032;, C(&#x2550;O)OR&#x2032;, NO, NH, NHR&#x2032;, N(R&#x2032;), NHC(O)R&#x2032;, CN, halogen, &#x2550;O, substituted or unsubstituted C-Calkyl, substituted or unsubstituted C-Calkenyl, substituted or unsubstituted C-Calkynyl, substituted or unsubstituted aryl, substituted or unsubstituted heterocyclic; wherein X is independently selected of OR&#x2032;, CN, (&#x2550;O), or H; wherein each of the R&#x2032; groups is independently selected from the group consisting of H, OH, NO, NH, SH, CN, halogen, &#x2550;O, C(&#x2550;O)H, C(&#x2550;O)CH, COH, substituted or unsubstituted C-Calkyl, substituted or unsubstituted C-Calkenyl, substituted or unsubstituted C-Calkynyl, substituted or unsubstituted aryl; wherein m is 0, 1 or 2; and wherein n is 0, 1, 2, 3, or 4, and their use as antitumoral agent. 

Ecteinascidin analogs for use as antitumour agents

Derivatives of Et-743 or Et-770 or Et-729 are provided. The derivatives are of the general formula (Ia) wherein the substituent groups take various permitted meanings. 

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Madrid, Spain

Valentin Martinez