Purdue Research Foundation

Val J Watts

Daniel Patrick Flaherty

Richard M Van Rijn

Jatinder Kaur

Mingji Dai

David E Nichols

Zhishi Ye

Jason A Scott

The present invention relates to a method of treatment for chronic pain, opioid dependence, alcohol use disorder or autism using a class of pyrimidinone compounds, an adenylyl cyclase 1 (AC1) inhibitor. The invention described herein also pertains to pharmaceutical compositions and methods for treating diseases in mammals using those compounds disclosed herein.

Pyrazolyl pyrimidinone compounds and the uses thereof

Scaffold of adenylyl cyclase inhibitors for chronic pain and opioid dependence

This present application disclosed a series of selective adenylyl cyclase 1 (AC1) inhibitors, compounds having a formula or a pharmaceutically acceptable salt thereof, as a pain therapeutic. Those compounds may provide an effective method of treatment for chronic/inflammatory pain. Those compounds may also prevent opioid dependence and/or reduce opioid dependence. Both method and composition matters are within the scope of this invention.

Adenylyl cyclase inhibitors for chronic pain and opioid dependence

The invention generally relates to adenylyl cyclase inhibitor compounds and methods for treating neuropathic or inflammatory pain by using those compounds.

Adenylyl cyclase inhibitors for neuropathic and inflammatory pain

Octahydrobenzoisoquinoline modulators of dopamine receptors are described herein. Methods for using octahydrobenzoisoquinoline modulators of dopamine receptors in the treatment of dopamine dysfunction are also described herein.

Octahydrobenzoisoquinoline modulators of dopamine receptors and uses therefor

Optionally substituted chromenoisoquinolines and analogs and derivatives thereof are described herein. In addition, syntheses of these compounds are described herein. In addition, uses of these compounds as dopamine receptor binding compounds are described herein.

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West Lafayette, IN, United States of America

Val J Watts