Lupin, Inc.

Vaibhav Madhukar Kalhapure

Rajender Kumar Kamboj

Vidya Ramdas

Amit Kumar Das

Deepak Sahebrao Walke

Venkata Poornapragnacharyulu Palle

Navnath Popat Karche

Rajeshkumar Maganlal Loriya

Talha Hussain Khan

Advait Arun Joshi

Moloy Manoj Banerjee

Ganesh Navinchandra Gote

Pradeep Rangrao Patil

Vinod Popatrao Vyavahare

Smita Aditya Bhoskar

Venkata P Palle

Moloy Banerjee

Laxmikant Shamlal Datrange

Nishant Ramnivasji Gupta

Ganesh Rajaram Jadhav

Disclosed are macrocyclic compounds having the general Formula (I) or (II) and their tautomeric forms, stereoisomers, pharmaceutically acceptable salts, hydrates, solvates and prodrugs thereof, and their combination with suitable medicament, corresponding processes for the synthesis and pharmaceutical compositions and uses of compounds disclosed herein.

Macrocyclic compounds as sting agonists and methods and uses thereof

The present invention relates to sulfonamide compounds Formula (I) wherein the substituents are as described herein, and their use in a medicine for the treatment of diseases, disorders associated with the inhibition of Voltage-gated sodium channels (VGSC) particularly Na1.7. It further relates to the compounds herein and their pharmaceutically acceptable salts thereof, pharmaceutical compositions thereof useful in treating diseases, disorders, syndromes and/or conditions associated with the inhibition of Voltage-gated sodium channels (VGSC) particularly Na1.7. The invention also relates to process for the preparation of the compounds of the invention. 

Sulfonamide compounds as voltage-gated sodium channel modulators

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Maharashtra, India

Vaibhav Madhukar Kalhapure