Advaxis, Inc.

University of Pennsylvania

Vafa Shahabi

Yvonne Paterson

Paulo Cesar Maciag

Anu Wallecha

John Rothman

Matthew Seavey

Nicola Mason

Paulo MaCiag

The present invention provides KLK3 peptides, FOLH1 peptides, recombinant polypeptides comprising same, recombinant nucleotide molecules encoding same, recombinantstrains comprising same, and immunogenic and therapeutic methods utilizing same.

Compositions and methods comprising KLK3 or FOLH1 antigen

Provided herein are recombinantstrains expressing a tumor-specific antigenic polypeptide and, optionally, an angiogenic polypeptide wherein a nucleic acid molecule encoding at least one of the polypeptides is operably integrated into thegenome in an open reading frame with a nucleic acid sequence encoding a PEST-containing polypeptide, methods of preparing same, and methods of inducing an immune response, and treating, inhibiting, or suppressing cancer or tumors comprising administering same.

Dual delivery system for heterologous antigens

This invention provides compositions and methods for treating and vaccinating against an Her2/neu antigen-expressing tumor and inducing an immune response against dominant and several sub-dominant epitopes of the antigen.

Compositions and methods for prevention of escape mutation in the treatment of HER2/NEU over-expressing tumors

This invention provides compositions and methods for treating and vaccinating against an Her2/neu antigen-expressing tumor and inducing an immune response against dominant in a non-human animal.

Growing community of inventors

Valley Forge, PA, United States of America

Vafa Shahabi