Rigel Pharmaceuticals, Incorporated

Vadim Markovtosov

Rajinder Paul Singh

Somasekhar Bhamidipati

Ankush Argade

Jeffrey Clough

Jiaxin Yu

Ihab S Darwish

Pingyu Ding

Hui Hong

Andy Atuegbu

Sambaiah Thota

Sambiah Thota

This invention is directed to compounds of formula (I): where n, m, Y, R, R, R, Rand Rare disclosed herein, as isolated stereoisomers or mixtures thereof, or pharmaceutically acceptable salts thereof; pharmaceutical compositions comprising the compounds of formula (I); and methods of using the compounds and the pharmaceutical compositions in treating diseases or conditions associated with JAK2 activity.

Pyrimidine-2-amine compounds and their use as inhibitors of JAK kinases

This invention is directed to compounds of formula (I): where n, m, Y, R, R, R, Rand Rare disclosed herein, as isolated stereoisomers or mixtures thereof, or as pharmaceutically acceptable salts thereof; pharmaceutical compositions comprising the compounds of formula (I); and methods of using the compounds and the pharmaceutical compositions in treating diseases or conditions associated with JAK2 activity.

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Foster City, CA, United States of America

Vadim Markovtosov