Eth Zurich

Ustav Organicke Chemie a Biochemie Av Cr, V.v.i.

Cf Plus Chemicals S.r.o.

Institute of Organic Chemistry and Biochemistry Academy of Sciences of the Czech Republic

Mikrobiologicky Ustav Av Cr, V.v.i.

Institute of Organic Chemistry and Biochemistry Academy of Sciences of the Czech Republic, V.v.i

Vaclav Matousek

Petr Beier

Antonio Togni

Petr Novak

Svatava Voltrova

Zsofia E Blastik

A method for functionalization of an aromatic amino acid or a nucleobase with a fluoroalkyl-containing moiety RF, wherein the aromatic amino acid is reacted in the presence of at least one reductant with at least one hypervalent iodine fluoroalkyl reagent carrying the fluoroalkyl-containing moiety RF is disclosed. Novel hypervalent iodine fluoroalkyl reagents is also disclosed.

Method for functionalization of an aromatic amino acid or a nucleobase

Described herein are hypervalent iodine reagents.

Hypervalent iodine CFCFX reagents and their use

Process for the preparation of azidoperfluoroalkanes and azidopolyfluoroalkanes of general formula R&#x2014;N, where Ris chosen from a group containing CF, CFH, CFXor RCFCF, where n is an integer in the range of 1 to 10, x is an integer in the range of 2 to 20, X is Cl, Br, or I, Ris Calkyl, ArO, ArS, imidazolyl, benzimidazolyl, or pyrazolyl and Ar is phenyl or substituted phenyl, by the reaction of electrophilic azidation reagent of general formula R&#x2014;N, where Ris n-CFSO, ArSO, Br, I, with synthetic equivalent of polyfluoroalkylated carbanion of general formula [R].

Process for the preparation of azidoperfluoroalkanes and N-polyfluoroalkyl azides

A hypervalent iodine of formula (I) or formula (II) wherein R is a nucleophile and a method for their production is described. Such compounds can be used for fluoroethylation of compounds carrying a reactive group. A preferred compound carrying a reactive group is cystein in any environment such as peptide targets.

Hypervalent iodine CF2CF2X reagents and their use

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Zliv, Czechia

Vaclav Matousek