Tel Aviv University

Ramot University Authority for Applied Research and Industrial Development Limited

Ramot University Authority for Applied Research and Industrial

Uzi Eliav

Gil Navon

Liat Tsoref

Arnon Neufeld

Dina Carasso

Yehuda Sharf

A novel MRI contrast technique enables to observe tissue properties not observable by previously known MRI methods. A difference between two disclosed pulse sequences is used to measure magnetization exchange time between water molecules and macromolecules such as proteins, thereby producing a measure highly sensitive to tissue changes resulting from coagulation, yet relatively insensitive to temperature fluctuations. This result is applied to an imaging method and provides direct visualization of the effects of surgical thermal ablation procedures.

MRI imaging and contrast method

A method of magnetic resonance analysis of a body having therein at least one molecular species and water is disclosed. The method comprises, subtracting magnetic resonance signals induced by a second radiofrequency pulse sequence from magnetic resonance signals induced by a first radiofrequency pulse sequence followed by a evolution period. The first radiofrequency pulse sequence is selected so as to suppress magnetization for the water while preserving a generally longitudinal magnetization to the at least one molecular species. The second radiofrequency pulse sequence being selected so as to suppress transverse and longitudinal magnetization for both the water and the at least one molecular species.

Method, apparatus and system for magnetic resonance analysis based on water magnetization transferred from other molecules

A method of magnetic resonance analysis of at least one type of molecules present in a solvent, the method comprises (a) applying a first radiofrequency pulse sequence selected so as to initially select a coherence of an order n for the at least one type of molecules in the solvent, wherein n is zero, a positive or a negative integer other than &#xb1;1, and thereafter to select an exclusive excitation of the at least one type of molecules in the solvent; (b) measuring at least one magnetic resonance parameter of the solvent; and (c) using the at least one magnetic resonance parameter of the solvent for calculating at least one magnetic resonance parameter of the at least one molecule.

Method of selective excitation for improving contrast in magnetic resonance imaging

A method of slice selective multiple quantum magnetic resonance imaging of an object is disclosed. The method is effected by implementing the steps of (a) applying a radiofrequency pulse sequence selected so as to select a coherence of an order n to the object, wherein n is zero, a positive or a negative integer other than &plusmn;1; (b) applying magnetic gradient pulses, so as to select a slice of the object to be imaged arid to create an image; and (c) acquiring a radiofrequency signal resulting from the object, so as to generate a magnetic resonance slice image of the object. The method provides slice selective multiple quantum magnetic resonance images of yet unprecedented quality in terms of contrast. The method is particularly useful for imaging connective tissues.

Method of magnetic resonance imaging

A method for depicting the anatomy and quantitative tissue strain of a biological tissue. A spatially resolved, double quantum filtered, nuclear magnetic resonance frequency spectrum is acquired from either .sup.1 H or .sup.2 H nuclei in the tissue. Values in the time domain or frequency domain representations of the free induction decay signal are mapped in 2 spatial dimensions so as to selectively depict histological layers of the tissue anatomy. The residual quadrupolar or dipolar splitting is calculated from the free induction decay signal, and then correlated with a tissue strain value by utilizing a known formula describing the correlation between residual quadrupolar or dipolar splitting and tissue strain. The tissue strain value is then mapped in two spatial dimensions.

Growing community of inventors

Tel Aviv, Israel

Uzi Eliav