Boehringer Ingelheim International Gmbh

Uwe Stertz

Marco Santagostino

Thorsten Pachur

Markus Frank

Ulrike Werthmann

Manuel Henry

Hans Haeberle

Thomas Trebing

Matthias Eckhardt

Georg Dahmann

Holger Wagner

Juergen Schnaubelt

This invention relates to co-crystals and salts of CCR3 inhibitors of formula 1, pharmaceutical compositions containing the same, and methods of using the same as agents for treatment and/or prevention of diseases related with the CCR3-receptor.

Co-crystals and salts of CCR3-inhibitors

The present invention relates to compounds of formula I wherein Rdenotes F or CF, Rdenotes H or C-alkyl and Z denotes a leaving group or an optionally substituted or protected hydroxyl group, suitable as intermediates in the synthesis of indanyloxydihydrobenzofuranylacetic acids, which are GPR40 agonists, to a process for preparing these intermediates and to the process for preparing the GPR40 agonists making use of an asymmetric catalytic hydrogenation reaction in the presence of a transition metal catalyst and a chiral auxiliary.

Process and intermediates for preparing GPR40 agonists

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Biberach an der Riss, Germany

Uwe Stertz