Massachusetts Institute of Technology

Nano-s Biotechnologie Gmbh

Avalon Globocare Corp.

Avalong Globocare Corp.

Uwe Sleytr

Shuguang Zhang

Rui Qing

David Jin

Margit Sara

Frank M Unger

Christoph Mader

Andreas Breitwieser

Bernhard Schuster

Wolfgang Kautek

The present invention is directed to QTY CCR9 and CXCR2 variant Fc receptor fusion proteins, methods for the preparation thereof and methods of use thereof.

QTY Fc fusion receptor proteins

QTY FC fusion receptor proteins

The invention includes a bioelectronic interface comprising a self-assembling unit, wherein the self-assembling unit comprises a variant GPCR fusion protein bound to an S-layer fusion protein. The invention also encompasses a biosensor or device comprising the bioelectronic interface and methods of screening for a ligand of a GPCR.

S-layer protein 2D lattice coupled detergent-free GPCR bioelectronic interfaces, devices, and methods for the use thereof

On a carrier surface, a layer of S-layer proteins is produced as a carrier of functional molecules. A solution containing S-layer proteins in the form of monomers or oligomers is brought into contact with the carrier surface. Electrochemical conditions are produced in the solution such that the S-layer proteins (SU) have an electrical net charge by establishing an electrochemical potential difference between the solution and the carrier surface such that the S-layer proteins accumulate on the carrier surface. A two-dimensional crystalline structure is formed in the layer, and this can occur at a time separate from the deposition of the S-layer proteins, and under different electrochemical conditions.

Method of depositing S-layer proteins on a carrier to immobilize functional molecules

A compound body can be constructed, using secondary cell wall polymers of prokaryotic microorganisms as bonding agent to anchor a monomolecular lattice to a support, with or without functional groups attached to the lattice. The lattice may be comprised of lipid or crystalline cell surface layer proteins. The support is illustrated by a micro-filtration membrane, a cell surface ultra-filtration membrane (SUM), and a micelle, respectively.

Use of secondary cell wall polymer of procaryotic microorganisms

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Vienna, Austria

Uwe Sleytr