Bayer Aktiengesellschaft

Bayer Pharma Aktiengesellschaft

Uwe Petersen

Karl G Metzger

Klaus Grohe

Thomas Schenke

Hans-Joachim Zeiler

Rainer Endermann

Andreas Krebs

Michael Schriewer

Klaus-Dieter Bremm

Ingo Haller

Peter Stadler

Stephan Bartel

Eckart Voss

Thomas Jaetsch

Klaus Dieter Bremm

Karl-Georg Metzger

Erich Klauke

Thomas Himmler

Thomas Philipps

Burkhard Mielke

Hans-Joachim Kabbe

Heinz-Georg Wetzstein

Harald Labischinski

Michael Stegemann

Bernd Baasner

Klaus Schaller

Michael Matzke

Hans-Otto Werling

Karl-Heinz Kuck

Michael Ruther

Ernst Kysela

Franz Kunisch

Martin Scheer

Siegfried Petersen

Engelbert Kuhle

Hans Scheinpflug

Hans-Georg Lerchen

Rolf Grosser

Wilfried Schrock

Dieter Habich

Michael Sperzel

Oswald Lockhoff

Karsten Von Dem Bruch

Horst-Peter Antonicek

J&ouml;rg Baumgarten

Ben Newton

Walter Weichel

Gabriele Schmuck

Axel Dalhoff

Brigitte Hamburger

Elmar Vilsmaier

Norbert Piel

Stefan B Ohm

Carl Kutzbach

Klaus Groche

Klaus Grobe

Thomas Sch&eacute;nke

Christoph Ladel

Gunther Milch

Torsten Goerz

The invention relates to inhalable quinolonecarboxylic acid derivative compositions for local control of diseases of the respiratory organs, in particular of lung diseases.

Treatment of bacterial diseases of the respiratory organs

The invention relates to the use of quinolone- and naphthyridonecarboxylic acid derivatives, which are substituted in the 7-position by a 2-oxa-5,8-diazabicyclo&lsqb;4.3.0&rsqb;-non-8-yl) radical, and their pharmaceutically utilizable hydrates and/or salts for the therapy of infections and the gastroduodenal disorders associated therewith.

USE OF 7-(2-OXA-5,8-DIAZABICYLCO&lsqb;4.3.0&rsqb;NON-8-YL)-QUINOLONE CARBOXYLIC ACID AND NAPHTHYRIDON CARBOXYLIC ACID DERIVATIVES FOR THE TREATMENT OF HELIOBACTER PYLORI INFECTIONS AND ASSOCIATED GASTRODUODENAL DISEASES

6-Amino-3-azabicyclo&lsqb;3.1.0&rsqb;hexanes of the formula

Special 3-azabicyclo&lsqb;3.1.0&rsqb;hexanes, method for producing and modifying the same, and their use

The invention relates to the use of quinolone- and naphthyridonecarboxylic acid derivatives which are substituted in position 7 by a 1-aminomethyl-2-oxa-7-azabicyclo&lsqb;3.3.0&rsqb;oct-7-yl radical, and of their salts for the therapy of,infections and associated gastroduodenal disorders.

Use of 7-(1-aminomethyl-2-oxa-7-aza-bicyclo&lsqb;3.3.0&rsqb;oct-7-yl)-quinolone carboxylic acid and naphthyridone carboxylic acid derivatives for treating Helicobacter pylori infections and the gastroduodenal diseases associated therewith

The invention relates to cytostatics which, by modification with sugar, are tumor-specific. Suitable spacers ensure serum stability and at the same time an intracellular action.

Sugar-modified cytostatics

Use of 7-(2-oxa-5,8-diazabicyclo[4.3.0]non-8-yl)-quinolone carboxylic

The invention relates to intermediate compounds for preparing novel quinolone derivatives- and naphthyridone derivatives which are substituted in the 7-position by a partially hydrogenated isoindolinyl ring, to processes for their preparation and to antibacterial agents and feed additives containing them.

7-isoindolinyl-quinolone derivatives and 7-isoindolinyl-naphthyridone

The invention relates to enantiomerically pure 2-oxa-5,8-diazabicyclo[4.3.0]nonanes and processes for their preparation.

Enantiomerically pure 2-oxa-5,8-dizaabicyclo[4.3.0] nonanes and process

The invention relates to new quinolone- and naphthyridonecarboxylic acid derivatives which are substituted in the 7-position by a tricyclic amine radical, their salts, processes for their preparation and antibacterial compositions comprising these compounds.

Quinolone- and naphthyridonecarboxylic acid derivatives

The invention is related to 7-amino-1-cyclopropyl-6,8-dihalogeno-1,4-dihydro-4-oxo-3-quinoline-carboxy lic acids of the formula (I) ##STR1## in which X.sup.1, X.sup.2, R.sup.1 and R.sup.2 have the meaning as pointed out in the following specification. Moreover, the invention is related to a process for the production of the compounds of formula (I) and to antibacterial agents containing them.

Intermediates for

The invention relates to new intermediate compounds for preparation of new quinolone- and naphthyridonecarboxylic acid derivatives which are substituted in the 7-position by an unsatured bicyclic amine radical, their salts, processes for their preparation and antibacterial compositions comprising these compounds.

Intermediate compounds for the preparation of new quinolone-and

2,4,5-Trihalogenobenzene derivatives of the formula ##STR1## in which R is --COOH, --COCl, --COF, --CN, --CONH.sub.2, --CH.sub.2 OH, --CH.sub.2 Cl, --CHCl.sub.2, --CCl.sub.3 or --CHO,

2, 4, 5-trihalogeno- and 2, 3, 4, 5-tetrahalogenobenzene derivatives

The invention relates to novel quinolone derivatives and naphthyridone derivatives which are substituted in the 7-position by a partially hydrogenated isoindolinyl ring, to processes for their preparation and to antibacterial agents and feed additives containing them.

Process for the preparation of antibacterial compounds of the formula ##STR1## comprises condensing an oxo compound of the formula ##STR2## with an amino compound of the formula ##STR3## to produce a compound of the formula ##STR4## reacting the compound of the formula (III) with a compound of the formula ##STR5## to give a compound of the formula ##STR6## and then eliminating the amino-protective group ##STR7##

Preparation of 7-(3-amino- and

Growing community of inventors

Leverkusen, Germany

Uwe Petersen