Roche Diagnostics Operations, Inc.

Roche Diagnostics Gmbh

F. Hoffmann-la Roche Ag

Uwe Mertsch

Stephan Sattler

Reinhold Kraemer

Reinhold Krämer

Michael Kuehnl

Marion Borchers

A method of monitoring detection of an analyte in a liquid sample using a measuring cell, the measuring cell comprising a working electrode for excitation of electrochemiluminescence in the liquid sample, an optical detector for detecting the excited electrochemiluminescence, the excitation and detection being performed in an measurement cycle, the measurement cycle comprising transporting the liquid sample via a transport path to the working electrode using a support liquid, the method comprising: coupling light of a light source into the transport path during part of the measurement cycle, the transport path forming a light guide between the light source and the optical detector, detecting the coupled light by the optical detector, analyzing the detected light for a gas bubble in the transport path, providing a measurement state if the result of the analysis deviates from a target state regarding the presence of a gas bubble in the transport path.

Method of monitoring an operation of detection of an analyte in a liquid sample

Decapping system for opening or closing reagent containers or cartridge systems closed by a lid which is removed and secured by a rotational movement and method thereof are disclosed. The decapping system has a centering unit at its lower end that provides a snap-in element which engages the lid, and a plurality of simultaneously driven and vertically movable screwing heads which compensates for variable heights and/or sizes of cartridge systems to be processed.

Method for unscrewing lids from a cartridge system

Decapping system

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Starnberg, Germany

Uwe Mertsch