Warner-lambert Company

Godecke Aktiengesellschaft

Uwe Gebhardt

Wolfgang Dieter Herrmann

Helmut Augart

Adolf Knecht

The present invention concerns cyclic amino acids of formula ##STR1## substantially free from the lactam ##STR2## wherein n is an integer of from 4 to 6, a process for the preparation thereof, compositions containing the compounds and methods of using them.

Lactam-free amino acids

A new process for the preparation of microcrystalline isoxicam having a particle size of about 1-30 .mu.m which comprises dissolving isoxicam in a mixture consisting of a solvent miscible with water and of an aqueous base where the resulting basic solution is neutralized with dilute acid to a pH of 4-6 with vigorous agitation precipitating the microcrystalline product is herein described.

Process for preparing microcrystalline isoxicam

The present invention provides a pharmaceutical composition containing at least one oxicam derivative of the general formula: ##STR1## in which R is a heterocyclic ring and X together with Y represent a condensed aromatic ring, together with a more than equimolar amount of an organic base of the general formula:

Growing community of inventors

Waldkirch, Germany

Uwe Gebhardt