Julius-maximilians-universitaet Wuerzburg

Ortus Medical Limited

Tetec Tissue Engineering Technologies Ag

Innotere Gmbh

Stuckensen, Kai

Uwe Gbureck

Juergen Groll

Kai Stuckensen

Jake E Barralet

Roger Thull

Jürgen Groll

Jake Barralet

The present invention relates to a monolithic multi-layered material having at least a first layer, from which anisotropic pores originate, and a second layer, in which the anisotropic pores continue. The present invention further relates to a monolithic medical material having at least a first layer, from which anisotropic pores originate, and a second layer, in which the anisotropic pores continue. The present invention further relates to a process for the production of a multi-layered material having anisotropic pores. It further relates to a multi-layered material which can be produced by the process according to the invention.

Production of materials having an anisotropic structure

The present invention relates to a process for the production of a multi-layered material having anisotropic pores. It further relates to a multi-layered material which can be produced by the process according to the invention, and to the use of a multi-layered material as a chondral support matrix, a meniscus support matrix or an intervertebral disc support matrix.

In a first aspect, the present invention discloses a self setting calcium phosphate cement comprising:&#x2014;(i) a powdered component, said powdered component having an average particle size dof less than 15 &#x3bc;m, and (ii) a calcium phosphate based powder, said powder having an average particle size dgreater than that of the powdered component, said powdered component and said calcium phosphate based powder being suspended in water containing a dissolved zeta potential increasing additive in sufficient quantity to increase the zeta potential of the suspended particles to at least 30 mV, and wherein the zeta potential increasing additive is chosen to be compatible with the setting pH of the same calcium phosphate cement without the zeta potential increasing additive. In a second aspect, the invention discloses a shelf-stable acidic setting cement powder comprising:&#x2014;(i) a calcium phosphate based powder, and (ii) a powdered compound which, upon addition of water to form a cement paste, retards the cement setting reaction or increases the zeta potential of the resultant suspended particles to at least &#x2212;30 mV.

Calcium phosphate bone cements

The invention relates to a preparation for a magnesium ammonium phosphate cement. There is provided a preparation comprising (a) a magnesium calcium phosphate of the formula MgCa(PO)O, wherein x+y&#x2266;4, x&#x3e;1, y&#x3e;0, z=x+y&#x2212;3 and z&#x2267;0; (b) an ammonium salt; and (c) water; wherein the ammonium salt and the water can be present partially or completely as an aqueous solution of the ammonium salt.

Growing community of inventors

Mellrichstadt, Germany

Uwe Gbureck