Zetascience Gmbh

Leibniz-institut Fur Polymerforschung Dresden E.v.

Denovomatrix Gmbh

Facellitate Gmbh

Technische Universitát Dresden

Deutsches Zentrum Fur Neurodegenerative Erkrankungen E. V.

Uwe Freudenberg

Carsten Werner

Mikhail Tsurkan

Yixin Zhang

Robert Wieduwild

Veronique Schwartz

Valentina Magno

Michael Seufert

Lars David Renner

Heather Weber

Petra Welzel

Marie-Francoise Gouzy

Dorit Meinhold

Passant Atallah

Caghan Kizil

Christos Papadimitriou

Marina Prewitz

Marle-Francoise Gouzy

Device D for cultivating cell cultures C, wherein said device D has a surface O and comprises on its surface O at least one polymer P wherein said polymer P is a copolymer of at least one monomer M and at least one ester E of (meth)acrylic acid and polyethylene oxide, wherein said monomer M is different from ester E and has at least one ethylenically unsaturated double bond.

Devices for cultivating cells coated with a copolymer of polyethyleneglykol (meth)acrylate

The present invention refers to a bioactive coating material for coating plastic materials for cell cultures, comprising a polymer conjugate of each a polymer anchor molecule having surface active anchoring groups and one or more biologically active molecules. The anchor molecule is an amphiphilic molecule with a hydrophobic moiety of styrene-, methacrylic acid-, isobutene-, acrylic acid-, acrylic acid ester-, or methacrylic acid ester units and a hydrophilic moiety of units including carboxyl-, amino-, epoxide-, thiol-, alkine- or azide groups. By selecting cell instructive coating materials cell destiny choices are individually and effectively controllable, in particular, the cell adhesion of almost any cell culture one-way articles by the user. With this concept, new options open up for high-throughput-diagnostics, stem cell-biotechnology and regenerative therapies.

Bioactive coating material

The invention relates to a method for the formation of renal tubules by embedding individual renal cells into a synthetic hydrogel, which is based on polyethylene glycol as a component, and the culturing of the cells until tubule structures are formed. The culturing can be continued until the obtained tubule structures correspond in terms of size, structure, morphology and functionality to adult human renal tubules or are at least similar thereto.

Method for the formation of renal tubules

The invention relates to a hydrogel matrix comprising a mixture of a covalent peptide-polymer conjugate and an oligosaccharide;

Non-covalent, self-organzing hydrogel matrix for biotechnological applications

The invention relates to a bioactive hydrogel as a hybrid material of heparin and star-branched polyethylene glycol with functionalized end groups, wherein the heparin is bound directly by reaction of the carboxyl groups activated with 1-ethyl-3-(3-dimethylaminopropyl) carbodiimides/N-hydroxysulfosuccinimide (EDC/s-NHS) with the terminal amino groups of the polyethylene glycol covalently by amide bonds.

Bioactive hydrogel

Growing community of inventors

Dresden, Germany

Uwe Freudenberg