Ipca Laboratories Limited

Uttamrao Arjunrao Sawant

Ashok Kumar

Dharmendra Singh

Ganesh Devidas Mahale

Swapnali Hemant Patil

Balasaheb Ganpat Jadhav

Ragneshkumar Rana

Disclosed herein is an industrial preparation of Quetiapine by the reaction of 11-piperazinyldibenzo[b,f][1,4]-thiazepine or its salt with 2-(2-chloroethoxy)ethanol in presence of an organic or inorganic base under neat or aqueous condition to form 11-[4-{2-(2-hydroxyethoxy)ethyl}-1-piperazinyl]dibenzo[b,f]-[1,4]thiazepine. The quetiapine free base obtained is further converted to its hemi-fumarate salt.

Industrial preparation of 11-[4-{2-(2-hydroxyethoxy) ethyl}-1-piperazinyl] dibenzo [b,f]-[1,4]thiazepine

The present invention discloses selective and complete reduction of pyridine ring in a biaryl system comprising &#x221d;-substituted or non-substituted benzene ring and relates more specifically, not exclusively, for the manufacture of methylphenidate, which is used for treatment of Attention Deficit Hyperactive Disorder (ADHD) and also acts as central nervous system stimulant, by using palladium/C in a solvent such as C1-C4 alcohols in presence of molar quantities of organic and/or inorganic acids.

Manufacturing process for methyl phenidate and intermediates thereof

Growing community of inventors

Maharashtra, India

Uttamrao Arjunrao Sawant